Semaglutide New

Name: Semaglutide
Brand: Tocris Bioscience
SKU: 8946

Tocris Bioscience, part of Bio-Techne | Catalog # 8946

COA / SDS

Highly potent, long-acting GLP-1 receptor agonist

Key Product Details

Description:	Highly potent, long-acting GLP-1 receptor agonist
Alternative Names:	NN-9535,NNC0480-0389
Purity:	≥95% (HPLC)
Molecular Weight:	4113.64

View Full Technical Details for Semaglutide

Technical Data
Citations

Biological Activity for Semaglutide

Semaglutide is a glucon-like peptide 1 analog and a potent and long-acting GLP-1R agonist. Upon activating GLP-1R, Semaglutide promotes insulin secretion, inhibits gastric emptying and appetite, causing lasting and reversible weight loss in normal and obese rats.

Semaglutide enhances autophagy by increasing the expression of LC3II, Atg7, Beclin-1 and P62; inhibits oxidative stress and apoptosis. Semaglutide has neuroprotective properties in a stroke animal model, where neurogenesis and growth factor cell signaling is normalized.

Semaglutide can be used for the study of neurodegenerative diseases and liver diseases such as type 2 diabetes, obesity, Parkinson's disease, metabolic associated fatty liver disease (MASLD), and cancer.

Technical Data for Semaglutide

M. Wt	4113.64
Formula	C₁₈₇H₂₉₁N₄₅O₅₉
Single Letter Sequence	HXEGTFTSDVSSYLEGQAAKEFIAWLVRGRG (Modifications: X = Aib, Lys-20 = C₁₈ diacid-γ-Glu-AEEA-AEEA-Lys)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	910463-68-2
PubChem ID	154733530
InChi Key	DLSWIYLPEUIQAV-CIIFZSTISA-N
Smiles	CC[C@@H]([C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](C(C)C)C(N[C@H](C(NCC(N[C@H](C(NCC(O)=O)=O)CCCNC(N)=N)=O)=O)CCCNC(N)=N)=O)=O)CC(C)C)=O)CC1=CNC2=C1C=CC=C2)=O)C)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](C(C)C)NC([C@@H](NC([C@@H](NC([C@H]([C@H](O)C)NC([C@@H](NC([C@H]([C@H](O)C)NC(CNC([C@@H](NC(C(C)(NC([C@H](CC3=CNC=N3)N)=O)C)=O)CCC(O)=O)=O)=O)=O)CC4=CC=CC=C4)=O)=O)CO)=O)CC(O)=O)=O)=O)CO)=O)CO)=O)CC5=CC=C(C=C5)O)=O)CC(C)C)=O)CCC(O)=O)=O)=O)CCC(N)=O)=O)C)=O)C)=O)CCCCNC(COCCOCCNC(COCCOCCNC(CC[C@@H](C(O)=O)NC(CCCCCCCCCCCCCCCCC(O)=O)=O)=O)=O)=O)=O)CCC(O)=O)=O)CC6=CC=CC=C6)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Semaglutide

Solubility

Soluble to 1mg/ml in water

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Semaglutide

References are publications that support the biological activity of the product.

Mahapatra Therapeutic potential of semaglutide, a newer GLP-1 receptor agonist, in abating obesity, non-Alcoholic steatohepatitis and neurodegenerative diseases: a narrative review. Pharm.Res. 2022 PMID: 35650449
Yang The diabetes drug semaglutide reduces infarct size, inflammation, and apoptosis, and normalizes neurogenesis in a rat model of stroke. Neuropharmacology 2019 PMID: 31465784
Chang Semaglutide-mediated protection against Aβ correlated with enhancement of autophagy and inhibition of apoptosis. J.Clin.Neurosc. 2020 PMID: 33222922
Gabery Semaglutide lowers body weight in rodents via distributed neural pathways. JCl Insight 2020 PMID: 32213703
Lau Discovery of the once-weekly glucagon-like peptide-1 (GLP-1) analogue semaglutide. J.Med.Chem 2015 PMID: 26308095
Knudsen The discovery and development of liraglutide and semaglutide. Front.Endocrinol. 2019 PMID: 31031702