SecinH3
Tocris Bioscience, part of Bio-Techne | Catalog # 2849
Sec7-specific GEF inhibitor; selective for cytohesin family
Key Product Details
Description
Sec7-specific GEF inhibitor; selective for cytohesin family
Product Description
SecinH3 is a Sec7-specific GEF inhibitor that displays selectivity for small GEFs of the cytohesin family (IC50 values are 2.4, 5.4, 5.4, 5.6, 5.6, 65 and > 100 μM for hCyh2, hCyh1, mCyh3, hCyh3, drosophila steppke, yGea2-S7 and hEFA6-S7 respectively). Inhibits insulin signaling via inhibition of insulin receptor substrate protein (IRS) phosphorylation.Product Specifications
Molecular Weight
460.50
Formula
C24H20N4O4S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-[4-[5-(1,3-Benzodioxol-5-yl)-3-methoxy-1H-1,2,4-triazol-1-yl]phenyl]-2-(phenylthio)acetamide
CAS Number
853625-60-2
PubChem ID
1029232
InChI Key
QPGYAMIHXLCFTJ-UHFFFAOYSA-N
SMILES
O=C(CSC5=CC=CC=C5)NC(C=C4)=CC=C4N1C(C2=CC(OCO3)=C3C=C2)=NC(OC)=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 46.05 | 100 |
Preparing Stock Solutions
for SecinH3
The following data is based on the product molecular weight 460.50
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.17 mL | 10.86 mL | 21.72 mL |
| 5 mM | 0.43 mL | 2.17 mL | 4.34 mL |
| 10 mM | 0.22 mL | 1.09 mL | 2.17 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.43 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Fuss The cytohesin Steppke is essential for Ins signalling in Drosophila. Nature 2006 PMID: 17167488
- Hafner Inhibition of cytohesins by secinH3 leads to hepatic Ins resistance. Nature 2006 PMID: 17167487
Product Specific Notices for SecinH3
For research use only
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