Scrambled ¹⁰Panx

Name: Scrambled 10 Panx
Brand: Tocris Bioscience
SKU: 3708

Tocris Bioscience, part of Bio-Techne | Catalog # 3708

Citations (8)

COA / SDS

Scrambled version of 10Panx (Cat. No. 3348), Panx-1 mimetic inhibitory peptide

Discontinued Product

3708 has been discontinued. View all Gap Channel Blockers products.

Key Product Details

Description:	Scrambled version of ¹⁰Panx (Cat. No. 3348), Panx-1 mimetic inhibitory peptide
Alternative Names:	^scPanx
Molecular Weight:	1242.37

View Full Technical Details for Scrambled ¹⁰Panx

Technical Data
Citations

Biological Activity for Scrambled ¹⁰Panx

Scrambled ¹⁰Panx is a scrambled version of ¹⁰Panx (Cat. No. 3348), a Panx-1 mimetic inhibitory peptide that blocks pannexin-1 gap junctions, inhibits P2X₇-mediated dye uptake, ATP-mediated IL-1β release and caspase-1 activation without altering membrane current in macrophages in vitro. ¹⁰Panx also blocks activation of NMDA receptor secondary currents (I_2nd) by > 70%.

Technical Data for Scrambled ¹⁰Panx

M. Wt	1242.37
Formula	C₅₈H₇₉N₁₅O₁₆
Single Letter Sequence	FSVYWAQADR
Storage	Store at -20°C
CAS Number	1315378-72-3
PubChem ID	90488872
InChi Key	VNQGVHMGXBRHRA-QZHJRRRASA-N
Smiles	[H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Scrambled ¹⁰Panx

References are publications that support the biological activity of the product.

Wang Modulation of membrane channel currents by gap junction protein mimetic peptides: size matters. Am.J.Physiol.Cell Physiol. 2007 PMID: 17652431
Thompson Activation of pannexin-1 hemichannels augments aberrant bursting in the hippocampus. Science 2008 PMID: 19056988
Pelegrin and Surprenant Pannexin-1 mediates large pore formation and interleukin-1β release by the ATP-gated P2X₇ receptor. EMBO J. 2006 PMID: 17036048

Scrambled ¹⁰Panx

Tocris Bioscience, part of Bio-Techne | Catalog # 3708

Key Product Details

Biological Activity for Scrambled ¹⁰Panx

Technical Data for Scrambled ¹⁰Panx

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Scrambled ¹⁰Panx

Product Documents for Scrambled ¹⁰Panx

COA

Certificate of Analysis

SDS

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Scrambled 10Panx

Tocris Bioscience, part of Bio-Techne | Catalog # 3708

Key Product Details

Biological Activity for Scrambled 10Panx

Technical Data for Scrambled 10Panx

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Scrambled 10Panx

Product Documents for Scrambled 10Panx

COA

Certificate of Analysis

SDS

Scrambled ¹⁰Panx

Biological Activity for Scrambled ¹⁰Panx

Technical Data for Scrambled ¹⁰Panx

References for Scrambled ¹⁰Panx

Product Documents for Scrambled ¹⁰Panx