10Panx
Tocris Bioscience, part of Bio-Techne | Catalog # 3348
Panx-1 mimetic inhibitory peptide; blocks pannexin-1 gap junctions
Key Product Details
Description
Panx-1 mimetic inhibitory peptide; blocks pannexin-1 gap junctions
Product Description
10Panx is a panx-1 mimetic inhibitory peptide that blocks pannexin-1 gap junctions. Inhibits P2X7-mediated dye uptake, ATP-mediated IL-1β release and caspase-1 activation without altering membrane current in macrophages in vitro. Also blocks activation of NMDA receptor secondary currents (I2nd) by > 70%.Product Specifications
Molecular Weight
1242.37
Formula
C58H79N15O16
Storage
Store at -20°C
Purity
≥95% (HPLC)
CAS Number
955091-53-9
PubChem ID
44233736
InChI Key
JCJASTVQGSKHKZ-QZHJRRRASA-N
SMILES
[H]N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 1mg/ml in water |
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Background References
References are publications that support the biological activity of the product.
- Wang Modulation of membrane channel currents by gap junction protein mimetic peptides: size matters. Am.J.Physiol.Cell Physiol. 2007 PMID: 17652431
- Thompson Activation of pannexin-1 hemichannels augments aberrant bursting in the hippocampus. Science 2008 PMID: 19056988
- Pelegrin and Surprenant Pannexin-1 mediates large pore formation and interleukin-1β; release by the ATP-gated P2X7 receptor. EMBO J. 2006 PMID: 17036048
Product Specific Notices for 10Panx
For research use only
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