SCH 79797 dihydrochloride

Product Description

SCH 79797 dihydrochloride is a potent, selective non-peptide PAR₁ receptor antagonist (IC₅₀ = 70 nM). Inhibits haTRAP-induced- but not γ-thrombin-, ADP- or collagen-induced human platelet aggregation. Selectively blocks PAR₁ agonist- or thrombin-induced increases in cytosolic Ca²⁺ in vascular smooth muscle cells. Also broad spectrum antibiotic. Kills bacteria by a dual action of inhibiting dihydrofolate reductase and interfering with bacterial cell membrane integrity.

Solubility

Preparing Stock Solutions for SCH 79797 dihydrochloride

The following data is based on the product molecular weight 444.41

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.50 mL	22.50 mL	45.00 mL
2.5 mM	0.90 mL	4.50 mL	9.00 mL
5 mM	0.45 mL	2.25 mL	4.50 mL
25 mM	0.09 mL	0.45 mL	0.90 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Martin A dual-mechanism antibiotic kills Gram-negative bacteria and avoids drug resistance. Cell 2020 PMID: 32497502
• Ahn Inhibition of cellular action of thrombin by N3-cyclopropyl-7-{[4-(1-methylethyl)phenyl]methyl}-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine (SCH 79797), a nonpeptide thrombin receptor antagonist. Biochem.Pharmacol. 2000 PMID: 11020444
• Lidington A role for proteinase-activated receptor 2 and PKC-ε in thrombin-mediated induction of decay-accelerating factor on human endothelial cells. Am.J.Physiol.Cell Physiol. 2005 PMID: 16079188
• Ahn Structure-activity relationships of pyrroloquinazolines as thrombin receptor antagonists. Bioorg.Med.Chem.Lett. 1999 PMID: 10450984