SCH 79797 dihydrochloride

Name: SCH 79797 dihydrochloride
Brand: Tocris Bioscience
SKU: 1592
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1592

Citations (41)

COA / SDS

Potent, selective non-peptide PAR1 antagonist

Key Product Details

Description:	Potent, selective non-peptide PAR₁ antagonist
Chemical Name:	N³-Cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	444.41

View Full Technical Details for SCH 79797 dihydrochloride

Technical Data
Citations

Biological Activity for SCH 79797 dihydrochloride

SCH 79797 dihydrochloride is a potent, selective non-peptide PAR₁ receptor antagonist (IC₅₀ = 70 nM). Inhibits haTRAP-induced- but not γ-thrombin-, ADP- or collagen-induced human platelet aggregation. Selectively blocks PAR₁ agonist- or thrombin-induced increases in cytosolic Ca²⁺ in vascular smooth muscle cells. Also broad spectrum antibiotic. Kills bacteria by a dual action of inhibiting dihydrofolate reductase and interfering with bacterial cell membrane integrity.

Compound Libraries for SCH 79797 dihydrochloride

SCH 79797 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SCH 79797 dihydrochloride

M. Wt	444.41
Formula	C₂₃H₂₅N₅.2HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1216720-69-2
PubChem ID	45073452
InChi Key	NNJTXSQXGHYXAJ-UHFFFAOYSA-N
Smiles	Cl.Cl.CC(C)C1=CC=C(CN2C=CC3=C2C=CC2=NC(NC4CC4)=NC(N)=C32)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SCH 79797 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	2.22	5
	DMSO	22.22	50

Preparing Stock Solutions for SCH 79797 dihydrochloride

The following data is based on the product molecular weight 444.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.50 mL	22.50 mL	45.00 mL
2.5 mM	0.90 mL	4.50 mL	9.00 mL
5 mM	0.45 mL	2.25 mL	4.50 mL
25 mM	0.09 mL	0.45 mL	0.90 mL

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Reconstitution Calculator

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References for SCH 79797 dihydrochloride

References are publications that support the biological activity of the product.

Martin A dual-mechanism antibiotic kills Gram-negative bacteria and avoids drug resistance. Cell 2020 PMID: 32497502
Ahn Inhibition of cellular action of thrombin by N3-cyclopropyl-7-{[4-(1-methylethyl)phenyl]methyl}-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine (SCH 79797), a nonpeptide thrombin receptor antagonist. Biochem.Pharmacol. 2000 PMID: 11020444
Lidington A role for proteinase-activated receptor 2 and PKC-ε in thrombin-mediated induction of decay-accelerating factor on human endothelial cells. Am.J.Physiol.Cell Physiol. 2005 PMID: 16079188
Ahn Structure-activity relationships of pyrroloquinazolines as thrombin receptor antagonists. Bioorg.Med.Chem.Lett. 1999 PMID: 10450984