SCH 202676 hydrobromide
Tocris Bioscience, part of Bio-Techne | Catalog # 1400
Inhibitor of ligand binding to G-protein-coupled receptors
Key Product Details
Description
Inhibitor of ligand binding to G-protein-coupled receptors
Product Description
SCH 202676 hydrobromide is a sulphydryl-reactive compound that inhibits agonist and antagonist binding to G-protein-coupled receptors. Inhibits a variety of GPCRs including adenosine, opioid, muscarinic, adrenergic and dopaminergic receptors (IC50 values are 0.1-1.8 μM).Product Specifications
Molecular Weight
348.26
Formula
C15H13N3S.HBr
Storage
Desiccate at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-(2,3-Diphenyl-1,2,4-thiadiazol-5(2H)-ylidene)methanamine hydrobromide
CAS Number
265980-25-4
PubChem ID
9884675
InChI Key
YJYGOWVFDGULLL-UHFFFAOYSA-N
SMILES
C\N=C1SN(C3=CC=CC=C3)C(C2=CC=CC=C2)=N/1.Br
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 8.71 | 25 with gentle warming |
Preparing Stock Solutions
for SCH 202676 hydrobromide
The following data is based on the product molecular weight 348.26
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 11.49 mL | 57.43 mL | 114.86 mL |
| 1.25 mM | 2.30 mL | 11.49 mL | 22.97 mL |
| 2.5 mM | 1.15 mL | 5.74 mL | 11.49 mL |
| 12.5 mM | 0.23 mL | 1.15 mL | 2.30 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Gao Effects of the allosteric modulator SCH-202676 on adenosine and P2Y receptors. Life Sci. 2004 PMID: 15081581
- Lewandowicz The 'allosteric modulator' SCH-202676 disrupts G protein-coupled receptor function via sulphydryl-sensitive mechanisms. Br.J.Pharmacol. 2006 PMID: 16402041
- Fawzi SCH-202676: an allosteric modulator of both agonist and antagonist binding to G protein-coupled receptors. Mol.Pharmacol. 2001 PMID: 11125021
Product Specific Notices for SCH 202676 hydrobromide
For research use only
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