SC 79
Tocris Bioscience, part of Bio-Techne | Catalog # 4635
Akt activator
Product Description
SC 79 is an activator of Akt; binds to the pleckstrin homology domain of Akt. Enhances Akt phosphorylation by upstream protein kinases; also enables cytosolic activation of Akt. Shown to suppress excitotoxicity-induced neuronal death in vitro and in vivo. Exhibits brain penetrance.Product Specifications
Molecular Weight
364.78
Formula
C17H17ClN2O5
Storage
Store at -20°C
Chemical Name
2-Amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester
CAS Number
305834-79-1
PubChem ID
2810830
InChI Key
DXVKFBGVVRSOLI-UHFFFAOYSA-N
SMILES
NC2=C(C(OCC)=O)C(C(C(OCC)=O)C#N)C1=CC(Cl)=CC=C1O2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.48 | 100 |
Preparing Stock Solutions
for SC 79
The following data is based on the product molecular weight 364.78
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.74 mL | 13.71 mL | 27.41 mL |
| 5 mM | 0.55 mL | 2.74 mL | 5.48 mL |
| 10 mM | 0.27 mL | 1.37 mL | 2.74 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.55 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Jo Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death. Proc.Natl.Acad.Sci.USA 2012 PMID: 22689977
Product Specific Notices for SC 79
For research use only
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