SB 747651A dihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 4630
Potent MSK1 inhibitor; also inhibits other AGC group kinases
Key Product Details
Description
Potent MSK1 inhibitor; also inhibits other AGC group kinases
Product Description
SB 747651A dihydrochloride is a potent, ATP-competitive mitogen- and stress-activated kinase 1 (MSK1) inhibitor (IC50 = 11 nM in an in vitro kinase assay); targets the N-terminal kinase domain. Inhibits MSK1, MSK2, PKA, PKB, RSK and p70S6K activity in cells. Blocks IL-10 production in macrophages.Licensing Information
Sold with the permission of GlaxoSmithKline.Product Specifications
Molecular Weight
415.32
Formula
C16H22N8O.2HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-N-4-piperidinyl-1H-imidazo[4,5-c]pyridine-7-methanamine dihydrochloride
CAS Number
1781882-72-1
PubChem ID
90488958
InChI Key
NRRCQHARLPNLHJ-UHFFFAOYSA-N
SMILES
NC1=NON=C1C3=NC2=CN=CC(CNC4CCNCC4)=C2N3CC.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 20.77 | 50 | |
| DMSO | 20.77 | 50 |
Preparing Stock Solutions
for SB 747651A dihydrochloride
The following data is based on the product molecular weight 415.32
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.82 mL | 24.08 mL | 48.16 mL |
| 2.5 mM | 0.96 mL | 4.82 mL | 9.63 mL |
| 5 mM | 0.48 mL | 2.41 mL | 4.82 mL |
| 25 mM | 0.10 mL | 0.48 mL | 0.96 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Bamford (1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: further optimisation as highly potent and selective MSK-1-inhibitors. Bioorg.Med.Chem.Lett. 2005 PMID: 15955699
- Naqvi Characterization of the cellular action of the MSK inhibitor SB-747651A. Biochem.J. 2012 PMID: 21970321
- Bamford (1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: a novel class of potent MSK-1-inhibitors. Bioorg.Med.Chem.Lett. 2005 PMID: 15950465
Product Specific Notices for SB 747651A dihydrochloride
For research use only
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