SB 408124

Name: SB 408124
Brand: Tocris Bioscience
SKU: 1963

Catalog # 1963 | Tocris Bioscience a Bio-Techne Brand

Citations (2)

COA / SDS

Selective non-peptide OX1 antagonist

Key Product Details

Description:	Selective non-peptide OX₁ antagonist
Chemical Name:	N-(6,8-Difluoro-2-methyl-4-quinolinyl)-N'-[4-(dimethylamino)phenyl]urea
Purity:	≥98% (HPLC)
Molecular Weight:	356.37

View Full Technical Details for SB 408124

Technical Data
Citations (2) / Reviews

Biological Activity for SB 408124

SB 408124 is a selective non-peptide orexin OX₁ receptor antagonist (K_b values are 21.7 and 1405 nM for human OX₁ and OX₂ receptors respectively). Blocks orexin-A induced grooming following oral administration in vivo.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data for SB 408124

M. Wt	356.37
Formula	C₁₉H₁₈F₂N₄O
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	288150-92-5
PubChem ID	4331799
InChi Key	JTARFZSNUAGHRB-UHFFFAOYSA-N
Smiles	CN(C)C1=CC=C(NC(=O)NC2=CC(C)=NC3=C(F)C=C(F)C=C23)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SB 408124

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	35.64	100

Preparing Stock Solutions for SB 408124

The following data is based on the product molecular weight 356.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.81 mL	14.03 mL	28.06 mL
5 mM	0.56 mL	2.81 mL	5.61 mL
10 mM	0.28 mL	1.40 mL	2.81 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

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References for SB 408124

References are publications that support the biological activity of the product.

Langmead Characterisation of the binding of [³H]-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor. Br.J.Pharmacol. 2004 PMID: 14691055
Porter Advances in novel 7-TM receptors: non-peptide orexin-1 antagonists. Royal Society of Chemistry Meeting.

Citations for SB 408124 (2)

Showing 1 - 2 of 2 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for SB 408124 include:

Suo et al. (2018) The Orexin-A-Regulated Akt/mTOR Pathway Promotes Cell Proliferation Through Inhibiting Apoptosis in Pancreatic Cancer Cells. Front Endocrinol (Lausanne). 9:647
PMID: 30429828
Urbałska et al. (2012) Orexins/hypocretins acting at Gi protein-coupled OX 2 receptors inhibit cyclic AMP synthesis in the primary neuronal cultures. BMC Cancer. 46:42561
PMID: 21547533

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