SB 3CT

Name: SB 3CT
Brand: Tocris Bioscience
SKU: 6088

Tocris Bioscience a Bio-Techne Brand

Catalog # 6088

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Key Product Details

Description:	High affinity and selective MMP2 inhibitor
Chemical Name:	2-[[(4-Phenoxyphenyl)sulfonyl]methyl]thiirane
Purity:	≥98% (HPLC)
Molecular Weight:	306.4

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Biological Activity for SB 3CT

SB 3CT is a selective high affinity MMP2 inhibitor (K_i = 28 nM); also inhibits MMP9 (K_i = 400 nM). Active in vivo, neuroprotective and blood-brain barrier permeable.

Technical Data for SB 3CT

M. Wt	306.4
Formula	C₁₅H₁₄O₃S₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	292605-14-2
PubChem ID	9883002
InChi Key	LSONWRHLFZYHIN-UHFFFAOYSA-N
Smiles	O=S(CC1CS1)(C2=CC=C(C=C2)OC3=CC=CC=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SB 3CT

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	30.64	100
	ethanol	6.13	20

Preparing Stock Solutions for SB 3CT

The following data is based on the product molecular weight 306.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.26 mL	16.32 mL	32.64 mL
5 mM	0.65 mL	3.26 mL	6.53 mL
10 mM	0.33 mL	1.63 mL	3.26 mL
50 mM	0.07 mL	0.33 mL	0.65 mL

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References for SB 3CT

References are publications that support the biological activity of the product.

Gooyit Selective gelatinase inhibitor neuroprotective agents cross the blood-brain barrier. ACS Chem.Neurosci. 2012 PMID: 23077716
Gu A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia. J.Neurosci. 2005 PMID: 16000631
Kleifeld X-ray absorption studies of human matrix metalloproteinase-2 (MMP-2) bound to a highly selective mechanism-based inhibitor. comparison with the latent and active forms of the enzyme. J.Biol.Chem. 2001 PMID: 11278946

Citations for SB 3CT

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