SB 399885 hydrochloride

Name: SB 399885 hydrochloride
Brand: Tocris Bioscience
SKU: 3189

Tocris Bioscience, part of Bio-Techne | Catalog # 3189

Citations (5)

COA / SDS

Potent and selective 5-HT6 antagonist

Key Product Details

Description:	Potent and selective 5-HT₆ antagonist
Chemical Name:	N-(3,5-Dichloro-2-methoxyphenyl)-4-methoxy-3-(1-piperazinyl)benzenesulfonamide hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	482.81

View Full Technical Details for SB 399885 hydrochloride

Technical Data
Citations

Biological Activity for SB 399885 hydrochloride

SB 399885 hydrochloride is a potent, brain penetrant, orally active 5-HT₆ antagonist. Displays > 200-fold selectivity for 5-HT₆ over other 5-HT receptors (pK_i values are 9.11, 8.81 and 9.02 for human recombinant, native rat and native human 5-HT₆ receptors respectively).

Compound Libraries for SB 399885 hydrochloride

SB 399885 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SB 399885 hydrochloride

M. Wt	482.81
Formula	C₁₈H₂₁Cl₂N₃O₄S.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	402713-81-9
PubChem ID	6918649
InChi Key	ATKZKAYWARYLBW-UHFFFAOYSA-N
Smiles	Cl.ClC1=CC(Cl)=CC(NS(C2=CC(N3CCNCC3)=C(OC)C=C2)(=O)=O)=C1OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SB 399885 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	48.28	100
	DMSO	48.28	100

Preparing Stock Solutions for SB 399885 hydrochloride

The following data is based on the product molecular weight 482.81.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.07 mL	10.36 mL	20.71 mL
5 mM	0.41 mL	2.07 mL	4.14 mL
10 mM	0.21 mL	1.04 mL	2.07 mL
50 mM	0.04 mL	0.21 mL	0.41 mL

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References for SB 399885 hydrochloride

References are publications that support the biological activity of the product.

Foley The selective 5-HT₆ receptor antagonists SB-271046 and SB-399885 potentiate NCAM PSA immunolabeling of dentate granule cells, but not neurogenesis, in the hippocampal formation of mature Wistar rats. Neuropharmacology 2008 PMID: 18455201
Hirst SB-399885 is a potent, selective 5-HT₆ receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models. Eur.J.Pharm. 2006 PMID: 1706979
Wesolowska and Nikiforuk Effects of the brain-penetrant and selective 5-HT₆ receptor antagonist SB-399885 in animal models of anxiety and depression. Neuropharmacology 2007 PMID: 17320917