SB 366791
Tocris Bioscience, part of Bio-Techne | Catalog # 1615
Potent and selective TRPV1 competitive antagonist
Key Product Details
Description
Potent and selective TRPV1 competitive antagonist
Product Description
SB 366791 is a potent, selective and competitive vanilloid TRPV1 receptor antagonist (pA2 = 7.71 at hVR1); antagonizes hTRPV1 receptors activated by agonists, noxious heat, but not protons. Displays selectivity over a wide range of receptors and systems including CB1 and CB2 receptors, voltage-gated Ca2+ channels and the hyperpolarization-activated current (Ih).Licensing Information
Sold for research purposes under agreement from GlaxoSmithKlineProduct Specifications
Molecular Weight
287.75
Formula
C16H14ClNO2
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
4'-Chloro-3-methoxycinnamanilide
CAS Number
472981-92-3
PubChem ID
667594
InChI Key
RYAMDQKWNKKFHD-JXMROGBWSA-N
SMILES
COC1=CC=CC(NC(=O)\C=C\C2=CC=C(Cl)C=C2)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.77 | 100 | |
| Ethanol | 2.88 | 10 |
Preparing Stock Solutions
for SB 366791
The following data is based on the product molecular weight 287.75
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.48 mL | 17.38 mL | 34.75 mL |
| 5 mM | 0.70 mL | 3.48 mL | 6.95 mL |
| 10 mM | 0.35 mL | 1.74 mL | 3.48 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.70 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Gavva Proton activation does not alter antagonist interaction with the capsaicin-binding pocket of TRPV1. Mol.Pharmacol. 2005 PMID: 16135784
- Gunthorpe Identification and characterisation of SB-366791, a potent and selective vanilloid receptor (VR1/TRPV1) antagonist. Neuropharmacology 2004 PMID: 14654105
- Fowler Inhibition of C6 glioma cell proliferation by anandamide, 1-arachidonylglycerol, and by a water soluble phosphate ester of anandamide: variability in response and involvement of arachidonic acid. Biochem.Pharmacol. 2003 PMID: 12948856
Product Specific Notices for SB 366791
For research use only
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