SB 297006

Name: SB 297006
Brand: Tocris Bioscience
SKU: 4213

Tocris Bioscience, part of Bio-Techne | Catalog # 4213

Citations (3)

COA / SDS

Potent and selective CCR3 antagonist

Key Product Details

Description:	Potent and selective CCR3 antagonist
Chemical Name:	N-Benzoyl-4-nitroaniline ethyl ester
Purity:	≥98% (HPLC)
Molecular Weight:	342.35

View Full Technical Details for SB 297006

Technical Data
Citations

Biological Activity for SB 297006

SB 297006 is a potent and selective CCR3 antagonist (IC₅₀ = 39 nM). Displays 250-fold selectivity for CCR3 over other chemokine receptors, including CXCR1, CXCR2, CCR1 and CCR7 (IC₅₀ >27 μM). Inhibits calcium mobilization induced by MCP-4, eotaxin-2 and eotaxin in RBL-2H3 cells transfected with CCR3 (IC₅₀ values are 80, 90 and 210 nM respectively).

Compound Libraries for SB 297006

SB 297006 is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for SB 297006

M. Wt	342.35
Formula	C₁₈H₁₈N₂O₅
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	58816-69-6
PubChem ID	9840971
InChi Key	BEZXGSZPWXRHIN-INIZCTEOSA-N
Smiles	O=C(C2=CC=CC=C2)N[C@H](C(OCC)=O)CC1=CC=C([N+]([O-])=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SB 297006

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	34.23	100
	ethanol	6.85	20

Preparing Stock Solutions for SB 297006

The following data is based on the product molecular weight 342.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.92 mL	14.60 mL	29.21 mL
5 mM	0.58 mL	2.92 mL	5.84 mL
10 mM	0.29 mL	1.46 mL	2.92 mL
50 mM	0.06 mL	0.29 mL	0.58 mL

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References for SB 297006

References are publications that support the biological activity of the product.

White Identification of a potent, selective non-peptide CC chemokine receptor-3 antagonist that inhibits eotaxin-, eotaxin-2-, and monocyte chemotactic protein-4-induced eosinophil migration. J.Biol.Chem. 2000 PMID: 10969084
Yoshimoto and Hansch Quantitative structure-activity relationships of D- and L-N-actyl-alpha-aminoamide ligands binding to chymotrypsin. On the problem of combined treatment of stereoisomers. J.Org.Chem. 1976 PMID: 932854