SB 297006
Tocris Bioscience, part of Bio-Techne | Catalog # 4213
Potent and selective CCR3 antagonist
Key Product Details
Description
Potent and selective CCR3 antagonist
Product Description
SB 297006 is a potent and selective CCR3 antagonist (IC50 = 39 nM). Displays 250-fold selectivity for CCR3 over other chemokine receptors, including CXCR1, CXCR2, CCR1 and CCR7 (IC50 >27 μM). Inhibits calcium mobilization induced by MCP-4, eotaxin-2 and eotaxin in RBL-2H3 cells transfected with CCR3 (IC50 values are 80, 90 and 210 nM respectively).Product Specifications
Molecular Weight
342.35
Formula
C18H18N2O5
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
N-Benzoyl-4-nitroaniline ethyl ester
CAS Number
58816-69-6
PubChem ID
9840971
InChI Key
BEZXGSZPWXRHIN-INIZCTEOSA-N
SMILES
O=C(C2=CC=CC=C2)N[C@H](C(OCC)=O)CC1=CC=C([N+]([O-])=O)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 34.23 | 100 | |
| Ethanol | 6.85 | 20 |
Preparing Stock Solutions
for SB 297006
The following data is based on the product molecular weight 342.35
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.92 mL | 14.60 mL | 29.21 mL |
| 5 mM | 0.58 mL | 2.92 mL | 5.84 mL |
| 10 mM | 0.29 mL | 1.46 mL | 2.92 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.58 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- White Identification of a potent, selective non-peptide CC chemokine receptor-3 antagonist that inhibits eotaxin-, eotaxin-2-, and monocyte chemotactic protein-4-induced eosinophil migration. J.Biol.Chem. 2000 PMID: 10969084
- Yoshimoto and Hansch Quantitative structure-activity relationships of D- and L-N-actyl-alpha-aminoamide ligands binding to chymotrypsin. On the problem of combined treatment of stereoisomers. J.Org.Chem. 1976 PMID: 932854
Product Specific Notices for SB 297006
For research use only
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