SB 277011A dihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 4207
Selective D3 antagonist
Product Description
SB 277011A dihydrochloride is a selective dopamine D3 receptor antagonist (pKi values are 8.0, 6.0, 5.0 and <5.2 for D3, D2, 5-HT1D and 5-HT1B respectively). Brain penetrant.Licensing Information
Sold for research purposes under agreement from GlaxoSmithKline.Product Specifications
Molecular Weight
511.49
Formula
C28H30N4O.2HCl
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-[trans-4-[2-(6-Cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]-4-quinolinecarboxamide dihydrochloride
CAS Number
1226917-67-4
PubChem ID
75358288
InChI Key
HEZIOTGUXSPDAK-UHFFFAOYSA-N
SMILES
O=C(N[C@@H]3CC[C@@H](CCN4CC(C=CC(C#N)=C5)=C5CC4)CC3)C1=C2C(C=CC=C2)=NC=C1.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 25.57 | 50 |
Preparing Stock Solutions
for SB 277011A dihydrochloride
The following data is based on the product molecular weight 511.49
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.91 mL | 19.55 mL | 39.10 mL |
| 2.5 mM | 0.78 mL | 3.91 mL | 7.82 mL |
| 5 mM | 0.39 mL | 1.96 mL | 3.91 mL |
| 25 mM | 0.08 mL | 0.39 mL | 0.78 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Stemp Design and synthesis of trans-N-[4-[2-(6-cyano-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]cyclohexyl]-4-quinolinecarboxamide (SB-277011): a potent and selective DA D3 receptor antagonist with high oral bioavailability and CNS pe J.Med.Chem. 2000 PMID: 10794704
- Reavill Pharmacological actions of a novel, high-affinity, and selective human DA D3 receptor antagonist, SB-277011-A. J.Pharmacol.Exp.Ther. 2000 PMID: 10945872
Product Specific Notices for SB 277011A dihydrochloride
For research use only
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