SB 277011A dihydrochloride

Name: SB 277011A dihydrochloride
Brand: Tocris Bioscience
SKU: 4207

Tocris Bioscience, part of Bio-Techne | Catalog # 4207

Citations (3)

COA / SDS

Selective D3 antagonist

Key Product Details

Description:	Selective D₃ antagonist
Chemical Name:	N-[trans-4-[2-(6-Cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]-4-quinolinecarboxamide dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	511.49

View Full Technical Details for SB 277011A dihydrochloride

Technical Data
Citations

Biological Activity for SB 277011A dihydrochloride

SB 277011A dihydrochloride is a selective dopamine D₃ receptor antagonist (pK_i values are 8.0, 6.0, 5.0 and <5.2 for D₃, D₂, 5-HT_1D and 5-HT_1B respectively). Brain penetrant.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline.

Technical Data for SB 277011A dihydrochloride

M. Wt	511.49
Formula	C₂₈H₃₀N₄O.2HCl
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1226917-67-4
PubChem ID	75358288
InChi Key	HEZIOTGUXSPDAK-UHFFFAOYSA-N
Smiles	O=C(N[C@@H]3CC[C@@H](CCN4CC(C=CC(C#N)=C5)=C5CC4)CC3)C1=C2C(C=CC=C2)=NC=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SB 277011A dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	25.57	50

Preparing Stock Solutions for SB 277011A dihydrochloride

The following data is based on the product molecular weight 511.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.91 mL	19.55 mL	39.10 mL
2.5 mM	0.78 mL	3.91 mL	7.82 mL
5 mM	0.39 mL	1.96 mL	3.91 mL
25 mM	0.08 mL	0.39 mL	0.78 mL

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References for SB 277011A dihydrochloride

References are publications that support the biological activity of the product.

Stemp Design and synthesis of trans-N-[4-[2-(6-cyano-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]cyclohexyl]-4-quinolinecarboxamide (SB-277011): a potent and selective DA D3 receptor antagonist with high oral bioavailability and CNS pe J.Med.Chem. 2000 PMID: 10794704
Reavill Pharmacological actions of a novel, high-affinity, and selective human DA D₃ receptor antagonist, SB-277011-A. J.Pharmacol.Exp.Ther. 2000 PMID: 10945872