SB 205607 dihydrobromide

Name: SB 205607 dihydrobromide
Brand: Tocris Bioscience
SKU: 0921

Catalog # 0921

Citations (2)

COA / SDS

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Key Product Details

Description:	Selective, high affinity non-peptide δ₁ agonist
Alternative Names:	TAN 67
Chemical Name:	(R,S)-(±)-2-Methyl-4aa-(3-hydroxyphenyl)-1,2,3,4,4a,5,12,12aa-octahydroquinolino[2,3,3-g]isoquinoline dihydrobromide
Purity:	≥97% (HPLC)
Molecular Weight:	506.28

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Biological Activity

The first described non-peptide δ₁ opioid receptor agonist with very high affinity and selectivity for the δ₁ subtype (K_i values are 1.12, 2320 and 1790 nM at δ₁, μ and κ receptors respectively).

Licensing Information

Sold under license

Compound Libraries

SB 205607 dihydrobromide is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	506.28
Formula	C₂₃H₂₄N₂O.2HBr
Storage	Store at RT
Purity	≥97% (HPLC)
CAS Number	1217628-73-3
PubChem ID	56972161
InChi Key	GWXFBFMLKRAWEU-YJKXCHRFSA-N
Smiles	[H][C@@](C1)2[C@](CC(N=C(C=CC=C4)C4=C3)=C3C2)([C@]5=CC=CC(O)=C5)CCN1C.Br.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	50.63	100
	DMSO	50.63	100

Preparing Stock Solutions

The following data is based on the product molecular weight 506.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.98 mL	9.88 mL	19.75 mL
5 mM	0.40 mL	1.98 mL	3.95 mL
10 mM	0.20 mL	0.99 mL	1.98 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

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References

References are publications that support the biological activity of the product.

Nagase The pharmacological profile of δ opioid receptor ligands (+) and (-) TAN-67 on pain modulation. Life Sci. 2001 PMID: 11358331
Kamei Antinociceptive effects of the selective non-peptidic δ-opioid receptor agonist TAN-67 in diabetic mice. Eur.J.Pharmacol. 1995 PMID: 7781682
Knap Properties of TAN-67, a non-peptidic β-opioid receptor agonist, at cloned human δ- and μ-opioid receptors. Eur.J.Pharmacol. 1995 PMID: 8566162
Nagase Syntheses of non-peptidic delta opioid agonists and their structure-activity relationships. Jpn.J.Pharmacol.

Citations for SB 205607 dihydrobromide (2)

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Citations are publications that use Bio-Techne products. Selected citations for SB 205607 dihydrobromide include:

Robins et al. (2018) Critical Role for Gi/o-Protein Activity in the Dorsal Striatum in the Reduction of Voluntary Alcohol Intake in C57Bl/6 Mice. Front Psychiatry. 9:112
PMID: 29686629
Nielsen et al. (2012) The delta opioid receptor antagonist, SoRI-9409, decreases yohimbine stress-induced reinstatement of ethanol-seeking. Addict Biol. 17:224
PMID: 21309957

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