Sanguinarine chloride
Tocris Bioscience, part of Bio-Techne | Catalog # 2302
Inhibitor of protein phosphatase 2C (PP2C)
Key Product Details
Description
Inhibitor of protein phosphatase 2C (PP2C)
Product Description
Sanguinarine chloride is an inhibitor of protein phosphatase 2C (PP2C), selective over PP1, PP2A and PP2B in vitro. Also inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) (IC50 = 10 μM). Plant alkaloid that exhibits anti-inflammatory and antioxidant activity. Blocks cell cycle in the G1 phase; inhibits cell growth in human prostate carcinoma cells.Product Specifications
Molecular Weight
367.78
Formula
C20H14ClNO4
Storage
Store at +4°C
Purity
≥97% (HPLC)
Chemical Name
13-Methyl-[1,3]-benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium chloride
CAS Number
5578-73-4
PubChem ID
68635
InChI Key
GIZKAXHWLRYMLE-UHFFFAOYSA-M
SMILES
C[N+]1=CC4=C(C=CC5=C4OCO5)C3=C1C2=CC(OCO6)=C6C=C2C=C3.[Cl-]
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 3.68 | 10 |
Preparing Stock Solutions
for Sanguinarine chloride
The following data is based on the product molecular weight 367.78
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27.19 mL | 135.95 mL | 271.90 mL |
| 0.5 mM | 5.44 mL | 27.19 mL | 54.38 mL |
| 1 mM | 2.72 mL | 13.60 mL | 27.19 mL |
| 5 mM | 0.54 mL | 2.72 mL | 5.44 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Aburai Sanguinarine as a potent and specific inhibitor of protein phosphatase 2C in vitro and induces apoptosis via phosphorylation of p38 in HL60 cells. Biosci.Biotechnol.Biochem. 2010 PMID: 20208361
- Adhami Sanguinarine causes cell cycle blockade and apoptosis of human prostate carcinoma cells via modulation of cyclin kinase inhibitor-cyclin-cyclin-dependent kinase machinery. Mol.Cell Ther.
- Vogt The benzo[c]phenanthridine alkaloid, sanguinarine, is a selective, cell-active inhibitor ofm mitogen-activated protein kinase phosphatase-1. J.Biol.Chem. 2005 PMID: 15753082
Product Specific Notices for Sanguinarine chloride
For research use only
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