SAG 21k
Tocris Bioscience, part of Bio-Techne | Catalog # 5282
Hedgehog signaling activator; brain penetrant and orally bioavailable
Key Product Details
Description
Hedgehog signaling activator; brain penetrant and orally bioavailable
Product Description
SAG 21k is a potent Hedgehog signaling activator (EC50 = 0.4 nM). Orally bioavailable and brain penetrant.Product Specifications
Molecular Weight
556.07
Formula
C29H28ClF2N3O2S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
3-Chloro-4,7-difluoro-N-[[2-methoxy-5-(4-pyridinyl)phenyl]methyl]-N-trans-4-(methylamino)cyclohexyl]benzo[b]thiophene-2-carboxamide
CAS Number
946002-48-8
PubChem ID
16678532
InChI Key
YVIFQUJDZSAFKG-UHFFFAOYSA-N
SMILES
COC1=C(CN([C@@H]2CC[C@@H](NC)CC2)C(C3=C(Cl)C4=C(C(F)=CC=C4F)S3)=O)C=C(C5=CC=NC=C5)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 55.61 | 100 | |
| Ethanol | 11.12 | 20 |
Preparing Stock Solutions
for SAG 21k
The following data is based on the product molecular weight 556.07
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.80 mL | 8.99 mL | 17.98 mL |
| 5 mM | 0.36 mL | 1.80 mL | 3.60 mL |
| 10 mM | 0.18 mL | 0.90 mL | 1.80 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.36 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Brunton Potent agonists of the Hedgehog signaling pathway. Bioorg.Med.Chem.Lett. 2009 PMID: 19500978
Product Specific Notices for SAG 21k
For research use only
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