SA 4503 dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 4951

Selective σ1 receptor agonist
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Key Product Details

Description

Selective σ1 receptor agonist

View all Sigma1 Receptor Agonists »

Product Description

SA 4503 dihydrochloride is a selective σ1 receptor agonist (IC50 = 17.4 nM). Exhibits selectivity for σ1 over σ2 receptors. Inhibits angiotensin II-induced cardiomyocyte hypertrophy in vitro and attenuates myocardial hypertrophy in vivo. Enhances brain plasticity and sensorimotor function in a rat model of experimental stroke.

Product Specifications

Molecular Weight

441.43

Formula

C23H32N2O2.2HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

1-[2-(3,4-Dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)-piperazine dihydrochloride

CAS Number

165377-44-6

PubChem ID

9954941

InChI Key

XWOXAKBQEMQMFH-UHFFFAOYSA-N

SMILES

COC1=C(OC)C=CC(CCN2CCN(CCCC3=CC=CC=C3)CC2)=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 44.14 100
DMSO 8.83 20

Preparing Stock Solutions for SA 4503 dihydrochloride

The following data is based on the product molecular weight 441.43

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.27 mL 11.33 mL 22.65 mL
5 mM 0.45 mL 2.27 mL 4.53 mL
10 mM 0.23 mL 1.13 mL 2.27 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for SA 4503 dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SA 4503 dihydrochloride

For research use only

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