SA-15-P
Tocris Bioscience, part of Bio-Techne | Catalog # 8050
Dual inhibitor of LAG3 interaction with both MHCII and FGL1
Key Product Details
Description
Dual inhibitor of LAG3 interaction with both MHCII and FGL1
Product Description
SA-15-P is a dual inhibitor of the interaction of lymphocyte activation gene 3 (LAG3) with both the major histocompatibility complex class II (MHCII) and fibrinogen-like protein 1 (FGL1) (IC50 values from TR-FRET assay are 4.2 μM and 6.5 μM respectively).Product Specifications
Molecular Weight
428.49
Formula
C26H24N2O4
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[4-[2-[2,5-Dimethyl-1-(phenylmethyl)-1H-pyrrol-3-yl]-2-oxoethoxy]phenyl]-2-furancarboxamide
CAS Number
852846-00-5
PubChem ID
4786555
InChI Key
IYGLJCOGIQDUAE-UHFFFAOYSA-N
SMILES
O=C(C1=CC=CO1)NC2=CC=C(C=C2)OCC(C3=C(C)N(CC4=CC=CC=C4)C(C)=C3)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 42.85 | 100 |
Preparing Stock Solutions
for SA-15-P
The following data is based on the product molecular weight 428.49
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.33 mL | 11.67 mL | 23.34 mL |
| 5 mM | 0.47 mL | 2.33 mL | 4.67 mL |
| 10 mM | 0.23 mL | 1.17 mL | 2.33 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.47 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Abdel-Rahman Discovery of first-in-class small molecule inhibitors of lymphocyte activation gene 3 (LAG-3). ACS Med.Chem.Lett. 2023 PMID: 37197466
Product Specific Notices for SA-15-P
For research use only
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