S4
Tocris Bioscience, part of Bio-Techne | Catalog # 5577
High affinity and selective CA IX and CA XII inhibitor
Key Product Details
Description
High affinity and selective CA IX and CA XII inhibitor
Product Description
S4 is a high affinity and selective CA IX and CA XII inhibitor (Ki values are 2, 7, 547 and 5600 nM for CA XII, IX, II and I, respectively). Inhibits migration and proliferation of breast cancer cells in vitro. Inhibits lung metastasis in mice bearing breast tumor xenografts, without affecting primary tumor.Product Specifications
Molecular Weight
335.38
Formula
C15H17N3O4S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
4-[[[(3,5-Dimethylphenyl)amino]carbonyl]amino]phenyl sulfamate
CAS Number
1330061-67-0
PubChem ID
53342705
InChI Key
HGVHSNXRZYOTPD-UHFFFAOYSA-N
SMILES
NS(OC1=CC=C(NC(NC2=CC(C)=CC(C)=C2)=O)C=C1)(=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.54 | 100 | |
| Ethanol | 6.71 | 20 |
Preparing Stock Solutions
for S4
The following data is based on the product molecular weight 335.38
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.98 mL | 14.91 mL | 29.82 mL |
| 5 mM | 0.60 mL | 2.98 mL | 5.96 mL |
| 10 mM | 0.30 mL | 1.49 mL | 2.98 mL |
| 50 mM | 0.06 mL | 0.30 mL | 0.60 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Gieling Antimetastatic effect of sulfamate carbonic anhydrase IX inhibitors in breast carcinoma xenografts. J.Med.Chem. 2012 PMID: 22621623
Product Specific Notices for S4
For research use only
Loading...
Loading...