(S)-WAY 100135 dihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 1253
Potent and selective 5-HT1A antagonist
Key Product Details
Description
Potent and selective 5-HT1A antagonist
Product Description
(S)-WAY 100135 dihydrochloride is a potent, selective 5-HT1A receptor antagonist (IC50 = 15 nM). Selective over 5-HT1B, 1C, 2,α1, α2 and D2 receptors (IC50 > 1000 nM). Centrally active on systemic administration.Licensing Information
Sold with the permission of Wyeth-Ayerst Research, US Patent 4,988,814Product Specifications
Molecular Weight
468.47
Formula
C24H33N3O2.2HCl
Storage
Desiccate at +4°C
Purity
≥98% (HPLC)
Chemical Name
(S)-N-tert-Butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenylpropanamide dihydrochloride
CAS Number
149007-54-5
PubChem ID
6604839
InChI Key
NYZFUZCCDOSQBG-AWEZNQCLSA-N
SMILES
O=C(NC(C)(C)C)[C@@]([C@]3=CC=CC=C3)([H])CN(CC2)CCN2C1=C(OC)C=CC=C1.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 4.68 | 10 with sonication | |
| water | 2.34 | 5 with gentle warming | |
| DMSO | 46.85 | 100 |
Preparing Stock Solutions
for (S)-WAY 100135 dihydrochloride
The following data is based on the product molecular weight 468.47
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.13 mL | 10.67 mL | 21.35 mL |
| 5 mM | 0.43 mL | 2.13 mL | 4.27 mL |
| 10 mM | 0.21 mL | 1.07 mL | 2.13 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.43 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Rodgers and Cole Anxiolytic-like effect of (S)-WAY 100135, a 5-HT1A receptor antagonist, in the murine elevated plus-maze test. Eur.J.Pharmacol. 1994 PMID: 7813555
- Fletcher WAY100135: a novel, selective antagonist at presynaptic and postsynaptic 5-HT1A receptors. Eur.J.Pharmacol. 1993 PMID: 8365456
- Fletcher Silent 5-HT1A receptor antagonists: utility as research tools and therapeutic agents. Trends Pharmacol.Sci. 1993 PMID: 8122313
- Cliffe (S)-N-tert-Butyl-3(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenylpropanamide [(S)-WAY-100135]: a selective antagonist at presynaptic and postsynaptic 5-HT1A receptors. J.Med.Chem. 1993 PMID: 8496920
Product Specific Notices for (S)-WAY 100135 dihydrochloride
For research use only
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