(S)-SNAP 5114

Tocris Bioscience, part of Bio-Techne | Catalog # 1561

GABA uptake inhibitor
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Key Product Details

Description

GABA uptake inhibitor

View all GABA Transporter Inhibitors »

Product Description

(S)-SNAP 5114 is a GABA transport inhibitor, showing selectivity for GAT-3 and GAT-2 (IC50 values are 5, 21 and 388 μM for hGAT-3, rGAT-2 and hGAT-1 respectively). Increases thalamic GABA levels and is an anticonvulsant following systemic administration in vivo.

Product Specifications

Molecular Weight

505.61

Formula

C30H35NO6

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

1-[2-[tris(4-methoxyphenyl)methoxy]ethyl]-(S)-3-piperidinecarboxylic acid

CAS Number

157604-55-2

PubChem ID

10458835

InChI Key

VDLDUZLDZBVOAS-QFIPXVFZSA-N

SMILES

O=[C@]([C@@H]1CN(CCOC(C3=CC=C(OC)C=C3)(C4=CC=C(OC)C=C4)C2=CC=C(OC)C=C2)CCC1)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 50.56 100
Ethanol 25.28 50

Preparing Stock Solutions for (S)-SNAP 5114

The following data is based on the product molecular weight 505.61

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.98 mL 9.89 mL 19.78 mL
5 mM 0.40 mL 1.98 mL 3.96 mL
10 mM 0.20 mL 0.99 mL 1.98 mL
50 mM 0.04 mL 0.20 mL 0.40 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for (S)-SNAP 5114

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for (S)-SNAP 5114

For research use only

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