(S)-(+)-Ketamine hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 4379
NMDA receptor antagonist; enantiomer of ketamine hydrochloride (Cat. No. 3131); neuroprotective
Key Product Details
Description
NMDA receptor antagonist; enantiomer of ketamine hydrochloride (Cat. No. 3131); neuroprotective
Product Description
(S)-(+)-Ketamine hydrochloride is a NMDA receptor antagonist. Displays neuroprotective efficacy in vitro.Racemate also available.
Product Specifications
Molecular Weight
274.19
Formula
C13H16ClNO.HCl
Storage
Store at RT
Purity
≥99% (HPLC)
Chemical Name
(S)-(+)-2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride
CAS Number
33643-47-9
PubChem ID
44632368
InChI Key
VCMGMSHEPQENPE-ZOWNYOTGSA-N
SMILES
O=C1[C@](C2=CC=CC=C2Cl)(NC)CCCC1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 27.42 | 100 | |
| DMSO | 27.42 | 100 |
Preparing Stock Solutions
for (S)-(+)-Ketamine hydrochloride
The following data is based on the product molecular weight 274.19
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.65 mL | 18.24 mL | 36.47 mL |
| 5 mM | 0.73 mL | 3.65 mL | 7.29 mL |
| 10 mM | 0.36 mL | 1.82 mL | 3.65 mL |
| 50 mM | 0.07 mL | 0.36 mL | 0.73 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Proescholdt Neuroprotection of S(+) KA isomer in global forebrain ischemia. Brain Res. 2001 PMID: 11406122
- Benrath Low dose of S(+)-KA prevents long-term potentiation in pain pathways under strong opioid analgesia in the rat spinal cord in vivo. Br.J.Anaesth. 2005 PMID: 16113037
- Ryder Comparative pharmacology of the optical isomers of KA in mice. Eur.J.Pharmacol. 1978 PMID: 658124
Product Specific Notices for (S)-(+)-Ketamine hydrochloride
For research use only
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