(S)-Duloxetine hydrochloride

Name: (S)-Duloxetine hydrochloride
Brand: Tocris Bioscience
SKU: 4798

Tocris Bioscience a Bio-Techne Brand

Catalog # 4798

Citations (1)

COA / SDS

Catalog #

Availability

Size / Price

Qty

Key Product Details

Description:	Potent 5-HT and NA reuptake inhibitor (SNRI); also blocks dopamine reuptake
Chemical Name:	(+)-(S)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	333.88

View Full Technical Details for (S)-Duloxetine hydrochloride

Biological Activity for (S)-Duloxetine hydrochloride

(S)-Duloxetine hydrochloride is a high affinity, competitive 5-HT and noradrenaline (NA) re-uptake inhibitor (K_i values are 8.5 and 45 nM for 5-HT and NA reuptake respectively in cortical synaptosomes; IC₅₀ values are 28 and 46 nM for 5-HT and NA reuptake respectively in rat hippocampal slices). Also blocks dopamine reuptake (K_i = 300 nM in striatal synaptosomes). Exhibits antidepressant and anxiolytic effects. Orally bioavailable.

Compound Libraries for (S)-Duloxetine hydrochloride

(S)-Duloxetine hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for (S)-Duloxetine hydrochloride

M. Wt	333.88
Formula	C₁₈H₁₉NOS.HCl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	136434-34-9
PubChem ID	60834
InChi Key	BFFSMCNJSOPUAY-LMOVPXPDSA-N
Smiles	CNCC[C@@H](C3=CC=CS3)OC2=CC=CC1=CC=CC=C12.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (S)-Duloxetine hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	3.34	10 with gentle warming
	DMSO	33.39	100

Preparing Stock Solutions for (S)-Duloxetine hydrochloride

The following data is based on the product molecular weight 333.88.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.00 mL	14.98 mL	29.95 mL
5 mM	0.60 mL	3.00 mL	5.99 mL
10 mM	0.30 mL	1.50 mL	3.00 mL
50 mM	0.06 mL	0.30 mL	0.60 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for (S)-Duloxetine hydrochloride

References are publications that support the biological activity of the product.

Kasamo Blockade of the serotonin and NE uptake processes by duloxetine: in vitro and in vivo studies in the rat brain. J.Pharmacol.Exp.Ther. 1996 PMID: 8613930
Wong LY227942, an inhibitor of serotonin and NE uptake: biochemical pharmacology of a potential antidepressant drug. Life Sci. 1988 PMID: 2850421

Citations for (S)-Duloxetine hydrochloride (1)

Showing 1 - 1 of 1 citation Showing All

Search Title:

Citations are publications that use Bio-Techne products. Selected citations for (S)-Duloxetine hydrochloride include:

Skelly and Weiner (2014) Chronic treatment with pra. or dulox. lessens concurrent anxiety-like behavior and alcohol intake: evidence of disrupted noradrenergic signaling in anxiety-related alcohol use. Brain Behav. 4:468
PMID: 25161814

There are no citations that match your criteria.

Showing 1 - 1 of 1 citation Showing All

Product Documents for (S)-Duloxetine hydrochloride

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.