(S)-Duloxetine hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 4798
Potent 5-HT and NA reuptake inhibitor (SNRI); also blocks dopamine reuptake
Key Product Details
Description
Potent 5-HT and NA reuptake inhibitor (SNRI); also blocks dopamine reuptake
Product Description
(S)-Duloxetine hydrochloride is a high affinity, competitive 5-HT and noradrenaline (NA) re-uptake inhibitor (Ki values are 8.5 and 45 nM for 5-HT and NA reuptake respectively in cortical synaptosomes; IC50 values are 28 and 46 nM for 5-HT and NA reuptake respectively in rat hippocampal slices). Also blocks dopamine reuptake (Ki = 300 nM in striatal synaptosomes). Exhibits antidepressant and anxiolytic effects. Orally bioavailable.Product Specifications
Molecular Weight
333.88
Formula
C18H19NOS.HCl
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
(+)-(S)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine hydrochloride
CAS Number
136434-34-9
PubChem ID
60834
InChI Key
BFFSMCNJSOPUAY-LMOVPXPDSA-N
SMILES
CNCC[C@@H](C3=CC=CS3)OC2=CC=CC1=CC=CC=C12.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 3.34 | 10 with gentle warming | |
| DMSO | 33.39 | 100 |
Preparing Stock Solutions
for (S)-Duloxetine hydrochloride
The following data is based on the product molecular weight 333.88
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.00 mL | 14.98 mL | 29.95 mL |
| 5 mM | 0.60 mL | 3.00 mL | 5.99 mL |
| 10 mM | 0.30 mL | 1.50 mL | 3.00 mL |
| 50 mM | 0.06 mL | 0.30 mL | 0.60 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kasamo Blockade of the serotonin and NE uptake processes by duloxetine: in vitro and in vivo studies in the rat brain. J.Pharmacol.Exp.Ther. 1996 PMID: 8613930
- Wong LY227942, an inhibitor of serotonin and NE uptake: biochemical pharmacology of a potential antidepressant drug. Life Sci. 1988 PMID: 2850421
Product Specific Notices for (S)-Duloxetine hydrochloride
For research use only
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