(S)-Crizotinib
Tocris Bioscience, part of Bio-Techne | Catalog # 6025
MTH1 inhibitor
Product Description
(S)-Crizotinib is a potent MTH1 inhibitor (IC50 = 72 nM). Induces DNA damage and disrupts nucleotide pool homeostasis in cancer cells. Also attenuates colony formation of KRAS-mutated PANC1 cells in vitro. Suppresses tumor growth ~50% in a colon cancer carcinoma xenograft model.Licensing Information
Sold for research purposes under agreement from Pfizer IncProduct Specifications
Molecular Weight
450.34
Formula
C21H22Cl2FN5O
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
3-[(1S)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine
CAS Number
1374356-45-2
PubChem ID
56671814
InChI Key
KTEIFNKAUNYNJU-LBPRGKRZSA-N
SMILES
C[C@@H](C1=C(C(F)=CC=C1Cl)Cl)OC2=CC(C3=CN(C4CCNCC4)N=C3)=CN=C2N
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 9.01 | 20 with gentle warming | |
| DMSO | 22.52 | 50 |
Preparing Stock Solutions
for (S)-Crizotinib
The following data is based on the product molecular weight 450.34
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.44 mL | 22.21 mL | 44.41 mL |
| 2.5 mM | 0.89 mL | 4.44 mL | 8.88 mL |
| 5 mM | 0.44 mL | 2.22 mL | 4.44 mL |
| 25 mM | 0.09 mL | 0.44 mL | 0.89 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Huber Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy. Nature 2014 PMID: 24695225
Product Specific Notices for (S)-Crizotinib
For research use only
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