(S)-(-)-Carbidopa

Name: ( S )-(-)-Carbidopa
Brand: Tocris Bioscience
SKU: 0455
Rating: 5 (1 reviews)

Catalog # 0455

(1)

COA / SDS

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Bio-Techne Corporation

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Key Product Details

Description:	Aromatic L-amino acid decarboxylase inhibitor
Chemical Name:	(S)-α-Hydrazino-α-methyl-β-(3,4-dihydroxyphenyl)propionic acid
Purity:	≥99% (HPLC)
Molecular Weight:	226.23

View Full Technical Details for (S)-(-)-Carbidopa

Biological Activity

(S)-(-)-Carbidopa is a peripheral decarboxylase inhibitor, used in combination with levodopa for treatment of Parkinsonism.

Technical Data

M. Wt	226.23
Formula	C₁₀H₁₄N₂O₄
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	28860-95-9
PubChem ID	34359
InChi Key	TZFNLOMSOLWIDK-JTQLQIEISA-N
Smiles	OC1=C(O)C=CC(C[C@@](NN)(C)C(O)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	4.52	20

Preparing Stock Solutions

The following data is based on the product molecular weight 226.23.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	22.10 mL	110.51 mL	221.01 mL
1 mM	4.42 mL	22.10 mL	44.20 mL
2 mM	2.21 mL	11.05 mL	22.10 mL
10 mM	0.44 mL	2.21 mL	4.42 mL

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References

References are publications that support the biological activity of the product.

Cheng Carbidopa inhibition of aromatic L-amino acid decarboxylase in rat brain capilliaries. FASEB J.
Kopfhammer L-Dopa infusion experiments in combination with the L-dopa decarboxylase inhibitors benserazide and carb. - L-dopa metabolism and neuroendocrinological effects. Pharmacopsychiatry

Citations for (S)-(-)-Carbidopa

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Carbidopa was used to understand it's effect on brain DDC conversion of levodopa/L-DOPA to dopamine

Name: Provs Pantha

Species: Human

Carbidopa acts as a peripheral DDC inhibitor, and carbidopa was used to understand it's effect on brain DDC conversion of levodopa/L-DOPA to dopamine.

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