(S)-(-)-5-Iodowillardiine

Name: ( S )-(-)-5-Iodowillardiine
Brand: Tocris Bioscience
SKU: 0307

Tocris Bioscience a Bio-Techne Brand

Catalog # 0307

Citations (2)

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Key Product Details

Description:	Highly potent and subtype-selective kainate agonist
Purity:	≥98% (HPLC)
Molecular Weight:	325.06

View Full Technical Details for (S)-(-)-5-Iodowillardiine

Biological Activity for (S)-(-)-5-Iodowillardiine

Demonstrates high affinity for the kainate receptor subtype hGluK1 (formerly hGluR5) (K_i = 0.24 nM) and 600-4000-fold selectivity over both the AMPA receptor subtypes and the homomeric kainate receptor hGluK2 (formerly hGluR6).

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Technical Data for (S)-(-)-5-Iodowillardiine

M. Wt	325.06
Formula	C₇H₈IN₃O₄
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	140187-25-3
PubChem ID	447196
InChi Key	AXXYLTBQIQBTES-BYPYZUCNSA-N
Smiles	O=C(N1)N(C[C@]([H])(N)C(O)=O)C=C(I)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (S)-(-)-5-Iodowillardiine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	1.1eq. NaOH	8.12	25

Preparing Stock Solutions for (S)-(-)-5-Iodowillardiine

The following data is based on the product molecular weight 325.06.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	12.31 mL	61.53 mL	123.05 mL
1.25 mM	2.46 mL	12.31 mL	24.61 mL
2.5 mM	1.23 mL	6.15 mL	12.31 mL
12.5 mM	0.25 mL	1.23 mL	2.46 mL

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References for (S)-(-)-5-Iodowillardiine

References are publications that support the biological activity of the product.

Swanson Kainate receptors exhibit differential sensitivities to (S)-5-iodowillardiine. Mol.Pharmacol. 1998 PMID: 9584222
Jane Synthesis of willardiine and 6-azawillardiine analogs: pharmacological characterization on cloned homomeric human AMPA and kainate receptor subtypes. J.Med.Chem. 1997 PMID: 9357531
Thompson Depolarising effects of certain derivatives of (S) willardiine upon in vitro neonatal rat dorsal roots. Br.J.Pharmacol.
Wong Willardiines differentiate agonist binding sites for kainate-versus AMPA-preferring glutamate receptors in DRG and hippocampal neurones. J.Neurosci. 1994 PMID: 7515954
Patneau Activation and desensitization of AMPA/kainate receptors by novel derivatives of willardiine. J.Neurosci. 1992 PMID: 1371315

Citations for (S)-(-)-5-Iodowillardiine (2)

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Citations are publications that use Bio-Techne products. Selected citations for (S)-(-)-5-Iodowillardiine include:

Pollok and Reiner (2020) Subunit-selective iGluR antagonists can potentiate heteromeric receptor responses by blocking desensitization. Proc Natl Acad Sci U S A. 117:25851
PMID: 32999066
Pansiot et al. (2010) Neuroprotective effect of inhaled nitric oxide on excitotoxic-induced brain damage in neonatal rat. Proc Natl Acad Sci U S A. 5:e10916
PMID: 20532231

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Product Documents for (S)-(-)-5-Iodowillardiine

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.