(S)-4-Carboxy-3-hydroxyphenylglycine

Name: ( S )-4-Carboxy-3-hydroxyphenylglycine
Brand: tocris
SKU: 0320

Catalog # 0320

Citations (1)

Datasheet / COA / SDS

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Key Product Details

Description:	Group I mGlu antagonist; also group II mGlu agonist
Alternative Names:	(S)-4C3HPG
Purity:	≥98% (HPLC)
Molecular Weight:	211.17

View Full Technical Details for (S)-4-Carboxy-3-hydroxyphenylglycine

Biological Activity

Competitive antagonist at group I mGlu_1a/1a receptors, mixed effect at mGlu_5a/5b receptors; agonist at group II metabotropic glutamate receptors.

Racemate also available.

Technical Data

M. Wt	211.17
Formula	C₉H₉NO₅
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	85148-82-9
PubChem ID	5311455
InChi Key	GXZSAQLJWLCLOX-ZETCQYMHSA-N
Smiles	OC1=C(C(O)=O)C=CC([C@]([H])(N)C(O)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	1eq. NaOH	21.12	100
	water	1.06	5

Preparing Stock Solutions

The following data is based on the product molecular weight 211.17.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.74 mL	23.68 mL	47.36 mL
5 mM	0.95 mL	4.74 mL	9.47 mL
10 mM	0.47 mL	2.37 mL	4.74 mL
50 mM	0.09 mL	0.47 mL	0.95 mL

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References

References are publications that support the biological activity of the product.

Birse Phenylglycine derivatives as new pharmacological tools for investigating the role of metabotropic glutamate receptors in the central nervous system Neuroscience 1993 PMID: 7680790
Hayashi Analysis of agonist and antagonist activities of phenylglycine derivatives for different cloned metabotropic glutamate receptor sub-types. J.Neurosci. 1994 PMID: 8182479
Kingston Pharmacological analysis of 4-carboxyphenylglycine derivatives: comparison of effects mGluR1α and mGluR5a subtypes. Neuropharmacology 1995 PMID: 8532170
Sekiyama Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes. Br.J.Pharmacol. 1996 PMID: 8730745

Citations (1)

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Citations are publications that use Bio-Techne products. Selected citations for (S)-4-Carboxy-3-hydroxyphenylglycine include:

Lee and Flavell (2014) Inhibition and enhancement of contextual fear memory destabilization. Front Behav Neurosci. 8:144
PMID: 24808841

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Product Datasheets

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

(S)-4-Carboxy-3-hydroxyphenylglycine

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Key Product Details

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Technical Data

Solubility

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Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References

Citations (1)

Product Datasheets

COA

Certificate of Analysis

SDS

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