RU 24969 hemisuccinate

Name: RU 24969 hemisuccinate
Brand: Tocris Bioscience
SKU: 0912
Rating: 5 (1 reviews)

Catalog # 0912

Citations (1)

(1)

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Key Product Details

Description:	5-HT_1A and 5-HT_1B agonist
Chemical Name:	5-Methoxy-3-(1,2,5,6-tetrahydro-4-pyridinyl)-1H-indole hemisuccinate
Purity:	≥99% (HPLC)
Molecular Weight:	287.34

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Biological Activity

RU 24969 hemisuccinate is a potent 5-HT_1A/1B and moderate 5-HT_2C agonist that may also release 5-HT. Centrally active following systemic administration.

Technical Data

M. Wt	287.34
Formula	C₁₄H₁₆N₂O.½C₄H₆O₄
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	66611-27-6
PubChem ID	3050530
InChi Key	BNYJLRQAWCQJOM-UHFFFAOYSA-N
Smiles	OC(=O)CCC(O)=O.COC1=CC=C2NC=C(C2=C1)C1=CCNCC1.COC1=CC=C2NC=C(C2=C1)C1=CCNCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	14.37	50
	water	8.62	30

Preparing Stock Solutions

The following data is based on the product molecular weight 287.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	6.96 mL	34.80 mL	69.60 mL
2.5 mM	1.39 mL	6.96 mL	13.92 mL
5 mM	0.70 mL	3.48 mL	6.96 mL
25 mM	0.14 mL	0.70 mL	1.39 mL

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References

References are publications that support the biological activity of the product.

Tomkins and O'Neill Effect of 5-HT_1B receptor ligands on self-administration of ethanol in an operant procedure in rats. Pharmacol.Biochem.Behav. 2000 PMID: 10837852
Gudermann Human S31 serotonin receptor clone encodes a 5-hydroxytryptamine_1E-like serotonin receptor. Mol.Pharmacol. 1993 PMID: 8450834
Guillaume Synthesis of 3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles and study of their serotonergic and antiDArgic properties. Eur.J.Med.Chem.

Citations for RU 24969 hemisuccinate (1)

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Citations are publications that use Bio-Techne products. Selected citations for RU 24969 hemisuccinate include:

Lawson et al. (2016) Effects of oxyt. on Serotonin 1B Agonist-induced Autism-like Behavior in Mice Behavioural Brain Research. 314:52
PMID: 27439030

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5-HT1B agonist-induced social and attention deficits in mice

Name: Anonymous

Species: Mouse

Assay Type: In Vivo

Cell Line/Tissue: brain

Drug treatment 0 or 10 mg/kg RU24969

PMID: 27439030 Reference

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