RU 24969 hemisuccinate

Name: RU 24969 hemisuccinate
Brand: Tocris Bioscience
SKU: 0912
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 0912

(1)

Citations (3)

COA / SDS

5-HT1A and 5-HT1B agonist

Key Product Details

Description:	5-HT_1A and 5-HT_1B agonist
Chemical Name:	5-Methoxy-3-(1,2,5,6-tetrahydro-4-pyridinyl)-1H-indole hemisuccinate
Purity:	≥99% (HPLC)
Molecular Weight:	287.34

View Full Technical Details for RU 24969 hemisuccinate

Technical Data
Citations / Reviews (1)

Biological Activity for RU 24969 hemisuccinate

RU 24969 hemisuccinate is a potent 5-HT_1A/1B and moderate 5-HT_2C agonist that may also release 5-HT. Centrally active following systemic administration.

Technical Data for RU 24969 hemisuccinate

M. Wt	287.34
Formula	C₁₄H₁₆N₂O.½C₄H₆O₄
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	66611-27-6
PubChem ID	3050530
InChi Key	BNYJLRQAWCQJOM-UHFFFAOYSA-N
Smiles	OC(=O)CCC(O)=O.COC1=CC=C2NC=C(C2=C1)C1=CCNCC1.COC1=CC=C2NC=C(C2=C1)C1=CCNCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for RU 24969 hemisuccinate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	14.37	50
	water	8.62	30

Preparing Stock Solutions for RU 24969 hemisuccinate

The following data is based on the product molecular weight 287.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	6.96 mL	34.80 mL	69.60 mL
2.5 mM	1.39 mL	6.96 mL	13.92 mL
5 mM	0.70 mL	3.48 mL	6.96 mL
25 mM	0.14 mL	0.70 mL	1.39 mL

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References for RU 24969 hemisuccinate

References are publications that support the biological activity of the product.

Tomkins and O'Neill Effect of 5-HT_1B receptor ligands on self-administration of ethanol in an operant procedure in rats. Pharmacol.Biochem.Behav. 2000 PMID: 10837852
Guillaume Synthesis of 3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles and study of their serotonergic and antiDArgic properties. Eur.J.Med.Chem.
Gudermann Human S31 serotonin receptor clone encodes a 5-hydroxytryptamine_1E-like serotonin receptor. Mol.Pharmacol. 1993 PMID: 8450834