(RS)-(±)-Sulpiride

Name: ( RS )-(±)-Sulpiride
Brand: Tocris Bioscience
SKU: 0894
Rating: 4 (2 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 0894

Citations (7)

(2)

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Key Product Details

Description:	Standard selective D₂-like antagonist
Chemical Name:	(RS)-(±)-5-Aminosulfonyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide
Purity:	≥99% (HPLC)
Molecular Weight:	341.42

View Full Technical Details for (RS)-(±)-Sulpiride

Biological Activity for (RS)-(±)-Sulpiride

(RS)-(±)-Sulpiride is a standard D₂-like dopamine receptor antagonist.

S-enantiomer also available.

Compound Libraries for (RS)-(±)-Sulpiride

(RS)-(±)-Sulpiride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for (RS)-(±)-Sulpiride

M. Wt	341.42
Formula	C₁₅H₂₃N₃O₄S
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	15676-16-1
PubChem ID	5355
InChi Key	BGRJTUBHPOOWDU-UHFFFAOYSA-N
Smiles	CCN1CCCC1CNC(=O)C1=C(OC)C=CC(=C1)S(N)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (RS)-(±)-Sulpiride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	1eq. HCl	17.07	50 with gentle warming
	DMSO	34.14	100

Preparing Stock Solutions for (RS)-(±)-Sulpiride

The following data is based on the product molecular weight 341.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.93 mL	14.64 mL	29.29 mL
5 mM	0.59 mL	2.93 mL	5.86 mL
10 mM	0.29 mL	1.46 mL	2.93 mL
50 mM	0.06 mL	0.29 mL	0.59 mL

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Reconstitution Calculator

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References for (RS)-(±)-Sulpiride

References are publications that support the biological activity of the product.

Seeman and Van Tol DA receptor pharmacology. TiPS 1994 PMID: 7940991
Seeman and Van Tol DA D₄ receptors bind inactive (+)-aporphines, suggesting neuroleptic role. Sulpiride not stereoselective. Eur.J.Pharmacol. 1993 PMID: 8097160

Citations for (RS)-(±)-Sulpiride (7)

Showing 1 - 7 of 7 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for (RS)-(±)-Sulpiride include:

Huang (2018) DA D1 Receptors Contribute Critically to the Apomorphine-Induced Inhibition of Form-Deprivation Myopia in Mice. Invest Ophthalmol Vis Sci. 59(6):2623
PMID: 29847669
Matsui and Alvarez (2018) Cocaine Inhibition of Synaptic Transmission in the Ventral Pallidum Is Pathway-Specific and Mediated by Serotonin. Cell Rep. 23(13):3852
PMID: 29949769
Zhang et al. (2018) DA Receptor Subtypes Mediate Opposing Effects on Form Deprivation Myopia in Pigmented Guinea Pigs. Invest Ophthalmol Vis Sci. 59(11):4441
PMID: 30193315
Leyrer-Jackson (2017) Subtype-specific effects of DArgic D2 receptor activation on synaptic trains in layer V pyramidal neurons in the mouse prefrontal cortex. Physiol Rep. 5(22):e13499
PMID: 29150590
Holroyd et al. (2015) Loss of feedback inhibition via D2 autoreceptors enhances acquisition of cocaine taking and reactivity to drug-paired cues. Brain. 40:1495
PMID: 25547712
Zhang et al. (2013) Sucrose produces withdrawal and DA-sensitive reinforcing effects in planarians. Physiol Behav. 112-113:8
PMID: 23415661
Shin et al. (2011) Exposure to extremely low frequency magnetic fields induces fos-related antigen-immunoreactivity via activation of DArgic d1 receptor. Neuropsychopharmacology. 20:130
PMID: 22110371

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Customer Reviews for (RS)-(±)-Sulpiride (2)

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Inhibition of Synaptic Transmission in the VP

Name: Anonymous

Species: Mouse

Assay Type: In Vivo

sulpiride (1 μM)

PMID: 29949769
Sulpiride reverses quinpirole effects on dopamine release

Name: Anonymous

Species: Mouse

Assay Type: Ex Vivo

In voltammetry experiments measuring evoked dopamine release, quinpirole was used to activate D2 receptors to inhibit dopamine release. Sulpiride (600 nM) was applied afterward to reverse quinpirole effects.

We mix sulpiride at 2mM in ethanol. It goes into solution well.

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Product Documents for (RS)-(±)-Sulpiride

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.