(RS)-APICA

Name: ( RS )-APICA
Brand: Tocris Bioscience
SKU: 1073

Catalog # 1073

Citations (2)

COA / SDS

Order Information

Bio-Techne Corporation

tel: (800) 343-7475 (free phone)

tel: (612) 379-2956

customercare.na@bio-techne.com

Shipping Information

$35 to United States

Products in stock will be shipped in 1-3 business days unless specified.

View Distributors

Key Product Details

Description:	Selective group II mGlu antagonist
Chemical Name:	(RS)-1-Amino-5-phosphonoindan-1-carboxylic acid
Molecular Weight:	257.18

View Full Technical Details for (RS)-APICA

Complete Your Research

Biological Activity

(RS)-APICA is a rigidified analog of MPPG (Cat. No. 0853); selective group II metabotropic glutamate receptor antagonist (IC₅₀ = 30 μM) with no significant effect on group I and III mGlu receptors at concentrations up to 1 mM. Increases extracellular glutamate concentrations and possesses unusual inverse agonist-like action.

Technical Data

M. Wt	257.18
Formula	C₁₀H₁₂NO₅P
Storage	Desiccate at +4°C
CAS Number	170847-18-4
PubChem ID	4694355
InChi Key	ZNQZXIHSJUDIKL-UHFFFAOYSA-N
Smiles	NC2(C(O)=O)CCC1=CC(P(O)(O)=O)=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	1.1eq. NaOH		100

Preparing Stock Solutions

The following data is based on the product molecular weight 257.18.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.89 mL	19.44 mL	38.88 mL
5 mM	0.78 mL	3.89 mL	7.78 mL
10 mM	0.39 mL	1.94 mL	3.89 mL
50 mM	0.08 mL	0.39 mL	0.78 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References

References are publications that support the biological activity of the product.

Xi Group II metabotropic glutamate receptors modulate extracellular glutamate in the nucleus accumbens. J.Pharmacol.Exp.Ther. 2002 PMID: 11752112
Krenz Group I, II and III mGluR compounds affect rhythm generation in the gastric circuit of the crustacean stomatogastric ganglion. J.Neurophysiol. 2000 PMID: 10712449
Ma Synthesis and biological activity of cyclic analogues of MPPG and MCPG as metabotropic glutamate receptor antagonists. Bioorg.Med.Chem.Lett.

Citations for (<em>RS</em>)-APICA (2)

Showing 1 - 2 of 2 citations Showing All

View all citations for the Small Molecules and Peptides platform.

Search Title:

Citations are publications that use Bio-Techne products. Selected citations for (RS)-APICA include:

Scholler (2017) HTS-compatible FRET-based conformational sensors clarify membrane receptor activation. Nat Chem Biol. 13(4):372
PMID: 28135236
Jiang et al. (2006) Activation of group III metabotropic glutamate receptors attenuates rotenone toxicity on DArgic neurons through a microtubule-dependent mechanism. J Neurosci. 26:4318
PMID: 16624952

There are no citations that match your criteria.