(RS)-APICA

Name: ( RS )-APICA
Brand: Tocris Bioscience
SKU: 1073

Tocris Bioscience a Bio-Techne Brand

Catalog # 1073

Citations (2)

COA / SDS

Discontinued Product

1073 has been discontinued. View all Group II mGluR Antagonists products.

Key Product Details

Description:	Selective group II mGlu antagonist
Chemical Name:	(RS)-1-Amino-5-phosphonoindan-1-carboxylic acid
Molecular Weight:	257.18

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Biological Activity for (RS)-APICA

(RS)-APICA is a rigidified analog of MPPG (Cat. No. 0853); selective group II metabotropic glutamate receptor antagonist (IC₅₀ = 30 μM) with no significant effect on group I and III mGlu receptors at concentrations up to 1 mM. Increases extracellular glutamate concentrations and possesses unusual inverse agonist-like action.

Technical Data for (RS)-APICA

M. Wt	257.18
Formula	C₁₀H₁₂NO₅P
Storage	Desiccate at +4°C
CAS Number	170847-18-4
PubChem ID	4694355
InChi Key	ZNQZXIHSJUDIKL-UHFFFAOYSA-N
Smiles	NC2(C(O)=O)CCC1=CC(P(O)(O)=O)=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (RS)-APICA

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	1.1eq. NaOH		100

Preparing Stock Solutions for (RS)-APICA

The following data is based on the product molecular weight 257.18.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.89 mL	19.44 mL	38.88 mL
5 mM	0.78 mL	3.89 mL	7.78 mL
10 mM	0.39 mL	1.94 mL	3.89 mL
50 mM	0.08 mL	0.39 mL	0.78 mL

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References for (RS)-APICA

References are publications that support the biological activity of the product.

Xi Group II metabotropic glutamate receptors modulate extracellular glutamate in the nucleus accumbens. J.Pharmacol.Exp.Ther. 2002 PMID: 11752112
Krenz Group I, II and III mGluR compounds affect rhythm generation in the gastric circuit of the crustacean stomatogastric ganglion. J.Neurophysiol. 2000 PMID: 10712449
Ma Synthesis and biological activity of cyclic analogues of MPPG and MCPG as metabotropic glutamate receptor antagonists. Bioorg.Med.Chem.Lett.

Citations for (RS)-APICA (2)

Showing 1 - 2 of 2 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for (RS)-APICA include:

Scholler (2017) HTS-compatible FRET-based conformational sensors clarify membrane receptor activation. Nat Chem Biol. 13(4):372
PMID: 28135236
Jiang et al. (2006) Activation of group III metabotropic glutamate receptors attenuates rotenone toxicity on DArgic neurons through a microtubule-dependent mechanism. J Neurosci. 26:4318
PMID: 16624952

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