(RS)-APICA

Name: ( RS )-APICA
Brand: Tocris Bioscience
SKU: 1073

Tocris Bioscience, part of Bio-Techne | Catalog # 1073

Citations (17)

COA / SDS

Selective group II mGlu antagonist

Discontinued Product

1073 has been discontinued. View all Group II mGluR Antagonists products.

Key Product Details

Description:	Selective group II mGlu antagonist
Chemical Name:	(RS)-1-Amino-5-phosphonoindan-1-carboxylic acid
Molecular Weight:	257.18

View Full Technical Details for (RS)-APICA

Technical Data
Citations

Biological Activity for (RS)-APICA

(RS)-APICA is a rigidified analog of MPPG (Cat. No. 0853); selective group II metabotropic glutamate receptor antagonist (IC₅₀ = 30 μM) with no significant effect on group I and III mGlu receptors at concentrations up to 1 mM. Increases extracellular glutamate concentrations and possesses unusual inverse agonist-like action.

Technical Data for (RS)-APICA

M. Wt	257.18
Formula	C₁₀H₁₂NO₅P
Storage	Desiccate at +4°C
CAS Number	170847-18-4
PubChem ID	4694355
InChi Key	ZNQZXIHSJUDIKL-UHFFFAOYSA-N
Smiles	NC2(C(O)=O)CCC1=CC(P(O)(O)=O)=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for (RS)-APICA

References are publications that support the biological activity of the product.

Xi Group II metabotropic glutamate receptors modulate extracellular glutamate in the nucleus accumbens. J.Pharmacol.Exp.Ther. 2002 PMID: 11752112
Ma Synthesis and biological activity of cyclic analogues of MPPG and MCPG as metabotropic glutamate receptor antagonists. Bioorg.Med.Chem.Lett.
Krenz Group I, II and III mGluR compounds affect rhythm generation in the gastric circuit of the crustacean stomatogastric ganglion. J.Neurophysiol. 2000 PMID: 10712449

(RS)-APICA

Tocris Bioscience, part of Bio-Techne | Catalog # 1073

Key Product Details

Biological Activity for (RS)-APICA

Technical Data for (RS)-APICA

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for (RS)-APICA

Product Documents for (RS)-APICA

COA

Certificate of Analysis

SDS

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