MPPG

Catalog # 0853

Citations (1)

COA / SDS

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Key Product Details

Description:	Group III and group II mGlu antagonist; more selective for group III than group II
Chemical Name:	(RS)-α-Methyl-4-phosphonophenylglycine
Molecular Weight:	245.17

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Biological Activity

MPPG is a potent antagonist of L-AP4-induced effects in rat spinal cord, thalamic and hippocampal neurons, showing selectivity over (1S,3S)-ACPD-induced effects. Potent antagonist of mGlu receptors linked to adenylyl cyclase in adult rat cortical slices.

Technical Data

M. Wt	245.17
Formula	C₉H₁₂NO₅P
Storage	Store at RT
CAS Number	169209-65-8
PubChem ID	3972752
InChi Key	PAONCRJPUQXPRW-UHFFFAOYSA-N
Smiles	NC(C(O)=O)(C)C1=CC=C(P(O)(O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	1eq. NaOH		100

Preparing Stock Solutions

The following data is based on the product molecular weight 245.17.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.08 mL	20.39 mL	40.79 mL
5 mM	0.82 mL	4.08 mL	8.16 mL
10 mM	0.41 mL	2.04 mL	4.08 mL
50 mM	0.08 mL	0.41 mL	0.82 mL

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References

References are publications that support the biological activity of the product.

Bedingfield Novel potent selective phenylglycine antagonists of metabotropic glutamate receptors. Eur.J.Pharmacol. 1996 PMID: 8864696
Bushell Pharmacological antagonism of the actions of group II and group III mGluR agonists in the lateral perforant path of rat hippocampal slices. Br.J.Pharmacol. 1996 PMID: 8730739
Salt and Turner Antagonism of the presumed presynaptic action of L-AP4 on GABAergic transmission in the ventrobasal thalamus by the novel mGluR anatagonist MPPG. Neuropharmacology 1996 PMID: 8734494
Jane New phenylglycine derivatives with potent and selective antagonist activity at presynaptic glutamate receptors in neonatal rat spinal cord. Neuropharmacology 1995 PMID: 8532166

Citations for MPPG (1)

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Citations are publications that use Bio-Techne products. Selected citations for MPPG include:

Dobson et al. (2015) Caffeine Modulates Vesicle Release and Recovery at Cerebellar Parallel Fibre Terminals, Independently of Calcium and Cyclic AMP Signalling. Mol Cancer Res. 10:e0125974
PMID: 25933382

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