MPPG

Name: MPPG
Brand: Tocris Bioscience
SKU: 0853

Tocris Bioscience, part of Bio-Techne | Catalog # 0853

Citations (1)

COA / SDS

Group III and group II mGlu antagonist; more selective for group III than group II

Discontinued Product

0853 has been discontinued. View all Group III mGluR Antagonists products.

Key Product Details

Description:	Group III and group II mGlu antagonist; more selective for group III than group II
Chemical Name:	(RS)-α-Methyl-4-phosphonophenylglycine
Molecular Weight:	245.17

View Full Technical Details for MPPG

Technical Data
Citations

Biological Activity for MPPG

MPPG is a potent antagonist of L-AP4-induced effects in rat spinal cord, thalamic and hippocampal neurons, showing selectivity over (1S,3S)-ACPD-induced effects. Potent antagonist of mGlu receptors linked to adenylyl cyclase in adult rat cortical slices.

Technical Data for MPPG

M. Wt	245.17
Formula	C₉H₁₂NO₅P
Storage	Store at RT
CAS Number	169209-65-8
PubChem ID	3972752
InChi Key	PAONCRJPUQXPRW-UHFFFAOYSA-N
Smiles	NC(C(O)=O)(C)C1=CC=C(P(O)(O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for MPPG

References are publications that support the biological activity of the product.

Salt and Turner Antagonism of the presumed presynaptic action of L-AP4 on GABAergic transmission in the ventrobasal thalamus by the novel mGluR anatagonist MPPG. Neuropharmacology 1996 PMID: 8734494
Bushell Pharmacological antagonism of the actions of group II and group III mGluR agonists in the lateral perforant path of rat hippocampal slices. Br.J.Pharmacol. 1996 PMID: 8730739
Jane New phenylglycine derivatives with potent and selective antagonist activity at presynaptic glutamate receptors in neonatal rat spinal cord. Neuropharmacology 1995 PMID: 8532166
Bedingfield Novel potent selective phenylglycine antagonists of metabotropic glutamate receptors. Eur.J.Pharmacol. 1996 PMID: 8864696

Product Documents for MPPG

COA

Certificate of Analysis is currently unavailable on-line. Please contact Customer Service.