(RS)-AMPA hydrobromide

Name: ( RS )-AMPA hydrobromide
Brand: Tocris Bioscience
SKU: 1074

Catalog # 1074 | Tocris Bioscience a Bio-Techne Brand

Citations (5)

COA / SDS

Selective AMPA agonist; more water soluble form of (RS)-AMPA (Cat. No. 0169)

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Key Product Details

Description:	Selective AMPA agonist; more water soluble form of (RS)-AMPA (Cat. No. 0169)
Chemical Name:	(RS)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid hydrobromide
Purity:	≥99% (HPLC)
Molecular Weight:	267.08

View Full Technical Details for (RS)-AMPA hydrobromide

Technical Data
Citations (5) / Reviews

Biological Activity for (RS)-AMPA hydrobromide

(RS)-AMPA hydrobromide is a more water soluble hydrobromide salt of (RS)-AMPA (Cat. No. 0169).

Technical Data for (RS)-AMPA hydrobromide

M. Wt	267.08
Formula	C₇H₁₀N₂O₄.HBr
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	171259-81-7
PubChem ID	11957558
InChi Key	KUAHVIUZGLGASU-UHFFFAOYSA-N
Smiles	Br.CC1=C(CC(N)C(O)=O)C(O)=NO1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (RS)-AMPA hydrobromide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	2.67	10 with gentle warming

Preparing Stock Solutions for (RS)-AMPA hydrobromide

The following data is based on the product molecular weight 267.08.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	37.44 mL	187.21 mL	374.42 mL
0.5 mM	7.49 mL	37.44 mL	74.88 mL
1 mM	3.74 mL	18.72 mL	37.44 mL
5 mM	0.75 mL	3.74 mL	7.49 mL

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References for (RS)-AMPA hydrobromide

References are publications that support the biological activity of the product.

Ko Screening of FDA-approved drugs using a MERS-CoV clinical isolate from South Korea identifies potential therapeutic options for COVID-19. Viruses 2021 PMID: 33918958
Honore The binding of ³H-AMPA, a structural analogue of glutamic acid, to rat brain membranes. J.Neurochem. 1982 PMID: 6125564
Krogsgaard-Larsen New class of glutamate agonist structurally related to ibotenic acid. Nature 1980 PMID: 6101908

Citations for (RS)-AMPA hydrobromide (5)

Showing 1 - 5 of 5 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for (RS)-AMPA hydrobromide include:

Pierrot et al. (2019) Sex-regulated gene dosage effect of PPARα on synaptic plasticity. Life Sci Alliance. 2
PMID: 30894406
Goo et al. (2017) Activity-dependent trafficking of lysosomes in dendrites and dendritic spines. J Cell Biol. 216:2499
PMID: 28630145
Iskandrani et al. (2015) Impact of subanesthetic doses of KA on AMPA-mediated responses in rats: An in vivo electrophysiological study on monoaminergic and glutamatergic neurons. J Neurosci. 29:792
PMID: 25759403
Chanda et al. (2013) Neurons generated by direct conversion of fibroblasts reproduce synaptic phenotype caused by autism-associated neuroligin-3 mutation. J Psychopharmacol. 110:16622
PMID: 24046374
Wasling et al. (2012) AMPA receptor activation causes silencing of AMPA receptor-mediated synaptic transmission in the developing hippocampus. PLoS One. 7:e34474
PMID: 22485173

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