RS 39604 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 0991
5-HT4 antagonist
Product Description
RS 39604 hydrochloride is a potent and selective 5-HT4 antagonist, with a pKi of 9.1 at 5-HT4 receptors in guinea pig striatal membranes and greater than 1000-fold selectivity over 5-HT1A, 2C, 3 and D1, D2, M1, M2, AT1, B1 and α1C receptors. The ketone group gives RS 39604 a relatively long half life; it is also orally active and so suitable for in vivo studies.Licensing Information
Sold with the permission of Roche BioscienceProduct Specifications
Molecular Weight
590.56
Formula
C26H36ClN3O6S.HCl
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
1-[4-Amino-5-chloro-2-(3,5-dimethoxyphenyl)methyloxy]-3-[1-[2-methylsulphonylamino]ethyl]piperidin-4-yl]propan-1-one hydrochloride
CAS Number
167710-87-4
PubChem ID
19081934
InChI Key
QSMYZGMJSGUWPM-UHFFFAOYSA-N
SMILES
Cl.COC1=CC(OC)=CC(COC2=CC(N)=C(Cl)C=C2C(=O)CCC2CCN(CCNS(C)(=O)=O)CC2)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 59.06 | 100 |
Preparing Stock Solutions
for RS 39604 hydrochloride
The following data is based on the product molecular weight 590.56
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.69 mL | 8.47 mL | 16.93 mL |
| 5 mM | 0.34 mL | 1.69 mL | 3.39 mL |
| 10 mM | 0.17 mL | 0.85 mL | 1.69 mL |
| 50 mM | 0.03 mL | 0.17 mL | 0.34 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hegde RS 39604: a potent, selective and orally active 5-HT4 receptor antagonist. Br.J.Pharmacol. 1995 PMID: 7582507
- Eglen Central 5-HT4 receptors TiPS 1995 PMID: 8578609
Product Specific Notices for RS 39604 hydrochloride
For research use only
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