RS 246204

Name: RS 246204
Brand: Tocris Bioscience
SKU: 8853

Tocris Bioscience, part of Bio-Techne | Catalog # 8853

COA / SDS

R-Spondin-1 substitute used to initiate small intestinal organoids

Key Product Details

Description:	R-Spondin-1 substitute used to initiate small intestinal organoids
Chemical Name:	3,7-Dihydro-3,7-dimethyl-8-(2-quinolinylthio)-1H-purine-2,6-dione
Purity:	≥98% (HPLC)
Molecular Weight:	339.37

View Full Technical Details for RS 246204

Technical Data
Citations

Biological Activity for RS 246204

RS 246204 is a R-Spondin-1 substitute. Able to initiate formation and growth of mouse intestinal organoids in media without R-Spondin-1 protein. In vivo, RS 24620 has regenerative effect in damaged intestinal epithelium mouse model.

Technical Data for RS 246204

M. Wt	339.37
Formula	C₁₆H₁₃N₅O₂S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	878451-87-7
PubChem ID	6485821
InChi Key	UHUHSGFUUWVRBO-UHFFFAOYSA-N
Smiles	O=C1NC(N(C)C2=C1N(C)C(SC3=CC=C4C=CC=CC4=N3)=N2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for RS 246204

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	1.7	5

Preparing Stock Solutions for RS 246204

The following data is based on the product molecular weight 339.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	58.93 mL	294.66 mL	589.33 mL
0.25 mM	11.79 mL	58.93 mL	117.87 mL
0.5 mM	5.89 mL	29.47 mL	58.93 mL
2.5 mM	1.18 mL	5.89 mL	11.79 mL

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References for RS 246204

References are publications that support the biological activity of the product.

Nam Effects of a small molecule R-spondin-1 substitute RS-246204 on a mouse intestinal organoid culture. Oncotarget 2017 PMID: 29464078