RS 23597-190 hydrochloride

Name: RS 23597-190 hydrochloride
Brand: Tocris Bioscience
SKU: 0728
Price: 114 USD

Tocris Bioscience a Bio-Techne Brand

Catalog # 0728

Citations (5)

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Key Product Details

Description:	5-HT₄ antagonist
Chemical Name:	3-(Piperidin-1-yl)propyl 4-amino-5-chloro-2-methoxybenzoate hydrochloride
Molecular Weight:	363.28

View Full Technical Details for RS 23597-190 hydrochloride

Biological Activity for RS 23597-190 hydrochloride

RS 23597-190 hydrochloride is a high affinity, selective competitive antagonist at 5-HT₄ receptors.

Licensing Information

Sold with the permission of Roche Bioscience

Technical Data for RS 23597-190 hydrochloride

M. Wt	363.28
Formula	C₁₆H₂₃ClN₂O₃.HCl
Storage	Store at RT
CAS Number	149719-06-2
PubChem ID	182592
InChi Key	QLZLBYYNMGQIAR-UHFFFAOYSA-N
Smiles	Cl.COC1=CC(N)=C(Cl)C=C1C(=O)OCCCN1CCCCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for RS 23597-190 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		100

Preparing Stock Solutions for RS 23597-190 hydrochloride

The following data is based on the product molecular weight 363.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.75 mL	13.76 mL	27.53 mL
5 mM	0.55 mL	2.75 mL	5.51 mL
10 mM	0.28 mL	1.38 mL	2.75 mL
50 mM	0.06 mL	0.28 mL	0.55 mL

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References for RS 23597-190 hydrochloride

References are publications that support the biological activity of the product.

Eglen Central 5-HT₄ receptors. TiPS 1995 PMID: 8578609
Eglen RS 23597-190: a potent and selective 5-HT₄ receptor antagonist. Br.J.Pharmacol. 1993 PMID: 8220871

Citations for RS 23597-190 hydrochloride (5)

Showing 1 - 5 of 5 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for RS 23597-190 hydrochloride include:

Du et al. (2015) Adrenergic and serotonin receptors affect retinal superoxide generation in diabetic mice: relationship to capillary degeneration and permeability. FASEB J. 29:2194
PMID: 25667222
Woo et al. (2007) Neuregulin-1 enhances depolarization-induced GABA release. Neuron. 54:599
PMID: 17521572
Huang and Kandel (2007) 5-Hydroxytryptamine induces a protein kinase A/mitogen-activated protein kinase-mediated and macromolecular synthesis-dependent late phase of long-term potentiation in the amygdala. J Pharmacol Exp Ther. 27:3111
PMID: 17376972
Kato et al. (2006) Direct GABAergic and glycinergic inhibition of the substantia gelatinosa from the rostral ventromedial medulla revealed by in vivo patch-clamp analysis in rats. J Neurosci. 26:1787
PMID: 16467527
Xiang et al. (2005) Modulation of spontaneous firing in rat subthalamic neurons by 5-HT receptor subtypes. J Neurophysiol. 93:1145
PMID: 15738272

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Showing 1 - 5 of 5 citations Showing All

Product Documents for RS 23597-190 hydrochloride

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.