RS 102221 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 1050
Selective 5-HT2C antagonist
Product Description
RS 102221 hydrochloride is a potent and selective 5-HT2C antagonist (pKi = 8.7). Displays ~ 100-fold selectivity over the 5-HT2A and 5-HT2B subtypes and is > 100-fold selective over other 5-HT receptors, α- and β-adrenergic and muscarinic ACh receptors.Licensing Information
Sold with the permission of Roche BioscienceProduct Specifications
Molecular Weight
649.08
Formula
C27H31F3N4O7S.HCl
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
8-[5-(2,4-Dimethoxy-5-(4-trifluoromethylphenylsulphonamido)phenyl-5-oxopentyl]-1,3,8-triazaspiro[4.5]decane-2,4-dione hydrochloride
CAS Number
187397-18-8
PubChem ID
18931299
InChI Key
SZJZEJZLRDIHPB-UHFFFAOYSA-N
SMILES
Cl.COC1=CC(OC)=C(NS(=O)(=O)C2=CC=C(C=C2)C(F)(F)F)C=C1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 100 |
Preparing Stock Solutions
for RS 102221 hydrochloride
The following data is based on the product molecular weight 649.08
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.54 mL | 7.70 mL | 15.41 mL |
| 5 mM | 0.31 mL | 1.54 mL | 3.08 mL |
| 10 mM | 0.15 mL | 0.77 mL | 1.54 mL |
| 50 mM | 0.03 mL | 0.15 mL | 0.31 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Bonhaus Absorption and brain penetration of a high affinity, highly selective 5-HT2C receptor antagonist, RS-102221. Ann.N.Y.Acad.Sci. 1998 PMID: 9928284
- Weinhardt Some benzenesulphonamido-substituted valerophenones that are selective antagonists for the 5-HT2C receptor. Bioorg.Med.Chem.Lett.
- Bonhaus RS-102221: a novel high affinity and selective 5-HT2C receptor antagonist. Neuropharmacology 1997 PMID: 9225287
Product Specific Notices for RS 102221 hydrochloride
For research use only
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