Rp-8-Br-PET-cGMPS

Name: Rp-8-Br-PET-cGMPS
Brand: Tocris Bioscience
SKU: 3028
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3028

(1)

Citations (21)

COA / SDS

Protein kinase G inhibitor

Key Product Details

Description:	Protein kinase G inhibitor
Chemical Name:	2-Bromo-3,4-dihydro-3-[3,5-O-[(R)-mercaptophosphinylidene]-β-D-ribofuranosyl]-6-phenyl-9H-Imidazo[1,2-a]purin-9-one sodium salt
Purity:	≥98% (HPLC)
Molecular Weight:	562.27

View Full Technical Details for Rp-8-Br-PET-cGMPS

Technical Data
Citations / Reviews (1)

Biological Activity for Rp-8-Br-PET-cGMPS

Rp-8-Br-PET-cGMPS is a competitive, reversible cGMP-dependent protein kinase (PKG) inhibitor; cGMP analog.

This product is sold in units of 560μg, equivalent to 1μmol.

Technical Data for Rp-8-Br-PET-cGMPS

M. Wt	562.27
Formula	C₁₈H₁₄BrN₅NaO₆PS
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	185246-32-6
PubChem ID	23695925
InChi Key	PNUXBFRWMZKKAJ-IPZAVTHYSA-M
Smiles	[H][C@@]([C@@](O[C@@H](N3C(Br)=NC5=C3NC4=NC(C6=CC=CC=C6)=CN4C5=O)[C@@H]2O)([H])CO1)2O[P@@]1(S[Na])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Rp-8-Br-PET-cGMPS

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	11.25	20
	DMSO	22.49	40

Preparing Stock Solutions for Rp-8-Br-PET-cGMPS

The following data is based on the product molecular weight 562.27.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.4 mM	4.45 mL	22.23 mL	44.46 mL
2 mM	0.89 mL	4.45 mL	8.89 mL
4 mM	0.44 mL	2.22 mL	4.45 mL
20 mM	0.09 mL	0.44 mL	0.89 mL

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References for Rp-8-Br-PET-cGMPS

References are publications that support the biological activity of the product.

Qi Protein kinase G regulates the basal tension and plays a major role in nitrovasodilator-induced relaxation of porcine coronary veins. Br.J.Pharmacol. 2007 PMID: 17891157
Valtcheva The commonly used cGMP-dependent protein kinase type I (cGKI) inhibitor Rp-8-Br-PET-cGMPS can activate cGKI in vitro and in intact cells. J.Biol.Chem. 2008 PMID: 19008225
Wei Identification of competitive antagonists of the rod photoreceptor cGMP-gated cation channel: beta-phenyl-1,N²-etheno-substituted cGMP analogues as probes of the cGMP-binding site. Biochemistry 1996 PMID: 8988020