Roscovitine

Tocris Bioscience, part of Bio-Techne | Catalog # 1332

Cdk inhibitor
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Key Product Details

Description

Cdk inhibitor

Alternative Names

CYC 202,Seliciclib

View all Cyclin-dependent Kinase Inhibitors »

Product Description

Roscovitine is a cyclin-dependent kinase (cdk) inhibitor. Displays sub-micromolar inhibition of cdk1, cdk2, cdk5, cdk7 and cdk9 (reported IC50 values range from 0.16 - 0.28 μM for cdk5 to 0.8 μM for cdk7). Selective for cdks over a wide range of related kinases including ERK1 and ERK2. Arrests L1210 cells in G1 phase. Inhibits phosphorylation of vimentin in vivo. Antimitotic.

Product Specifications

Molecular Weight

354.45

Formula

C19H26N6O

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(2R)-2-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol

CAS Number

186692-46-6

PubChem ID

160355

InChI Key

BTIHMVBBUGXLCJ-OAHLLOKOSA-N

SMILES

OC[C@@H](CC)NC1=NC(N(C(C)C)C=N2)=C2C(NCC3=CC=CC=C3)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.44 100
Ethanol 35.44 100

Preparing Stock Solutions for Roscovitine

The following data is based on the product molecular weight 354.45

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.82 mL 14.11 mL 28.21 mL
5 mM 0.56 mL 2.82 mL 5.64 mL
10 mM 0.28 mL 1.41 mL 2.82 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

Calculators

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for Roscovitine

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Roscovitine

For research use only

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