Ro 67-7476

Name: Ro 67-7476
Brand: Tocris Bioscience
SKU: 4346

Tocris Bioscience, part of Bio-Techne | Catalog # 4346

Citations (6)

COA / SDS

Positive allosteric modulator of mGlu1 receptors

Key Product Details

Description:	Positive allosteric modulator of mGlu₁ receptors
Chemical Name:	(2S)-2-(4-Fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-pyrrolidine
Purity:	≥98% (HPLC)
Molecular Weight:	319.39

View Full Technical Details for Ro 67-7476

Technical Data
Citations

Biological Activity for Ro 67-7476

Ro 67-7476 is a positive allosteric modulator of mGlu₁ receptors. Potentiates glutamate-induced calcium release (EC₅₀ = 60.1 nM at rat mGluR1a). Displays no activity at human mGlu₁ receptors.

Compound Libraries for Ro 67-7476

Ro 67-7476 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Ro 67-7476

M. Wt	319.39
Formula	C₁₇H₁₈FNO₂S
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	298690-60-5
PubChem ID	32681978
InChi Key	DAEHFYNGSSBGSS-KRWDZBQOSA-N
Smiles	FC(C=C2)=CC=[C@@]2[C@@H]1CCCN1S(C3=CC=C(C)C=C3)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ro 67-7476

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	31.94	100

Preparing Stock Solutions for Ro 67-7476

The following data is based on the product molecular weight 319.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.13 mL	15.65 mL	31.31 mL
5 mM	0.63 mL	3.13 mL	6.26 mL
10 mM	0.31 mL	1.57 mL	3.13 mL
50 mM	0.06 mL	0.31 mL	0.63 mL

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References for Ro 67-7476

References are publications that support the biological activity of the product.

Knoflach Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site. Proc.Natl.Acad.Sci.USA 2001 PMID: 11606768
Hemstapat A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators. Mol.Pharmacol. 2006 PMID: 16645124