Ro 60-0175 fumarate
Tocris Bioscience, part of Bio-Techne | Catalog # 1854
Potent, selective 5-HT2C agonist
Key Product Details
Description
Potent, selective 5-HT2C agonist
Product Description
Ro 60-0175 fumarate is a potent, selective 5-HT2 receptor agonist; shows selectivity for the 5-HT2C subtype (pKi values are 9, 7.5, 5.4, 5.2 and 5.6 for human 5-HT2C, 2A, 1A, 6 and 7 receptors respectively). Centrally active following oral or systemic administration in vivo.Product Specifications
Molecular Weight
342.75
Formula
C11H12ClFN2.C4H4O4
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
(αS)-6-Chloro-5-fluoro-α-methyl-1H-indole-1-ethanamine fumarate
CAS Number
169675-09-6
PubChem ID
6446435
InChI Key
CEPHEXXZGQBXGT-XZTIXWOLSA-N
SMILES
O=C(O)/C=C/C(O)=O.FC1=C(Cl)C=C(N(C[C@H](C)N)C=C2)C2=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 1.71 | 5 | |
| DMSO | 6.86 | 20 |
Preparing Stock Solutions
for Ro 60-0175 fumarate
The following data is based on the product molecular weight 342.75
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 14.59 mL | 72.94 mL | 145.88 mL |
| 1 mM | 2.92 mL | 14.59 mL | 29.18 mL |
| 2 mM | 1.46 mL | 7.29 mL | 14.59 mL |
| 10 mM | 0.29 mL | 1.46 mL | 2.92 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Jensen Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT2A/5-HT2C receptor agonists with pro-cognitive J.Med.Chem. 2013 PMID: 23301527
- Kennett Effects of Ro 60 0175, a 5-HT2C receptor agonist, in three animal models of anxiety. Eur.J.Pharmacol. 2000 PMID: 10650160
- Martin 5-HT2C receptor agonists: pharmacological characteristics and therapeutic potential. J.Pharmacol.Exp.Ther. 1998 PMID: 9694950
- Damjanoska Neuroendocrine evidence that (S)-2-(chloro-5-fluoro-indol-l-yl)-1-methylethylamine fumarate (Ro 60-0175) is not a selective 5-hydroxytryptamine2C receptor agonist. J.Pharmacol.Exp.Ther. 2003 PMID: 12604698
Product Specific Notices for Ro 60-0175 fumarate
For research use only
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