RO-3

Tocris Bioscience, part of Bio-Techne | Catalog # 3052

Selective P2X3 and P2X2/3 antagonist
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Key Product Details

Description

Selective P2X3 and P2X2/3 antagonist

View all P2X Receptor Antagonists »

Product Description

RO-3 is a selective homomeric P2X3 and heteromeric P2X2/3 receptor antagonist (pIC50 values are 7.0 and 5.9 respectively) that exhibits no activity at P2X1, P2X2, P2X4, P2X5 and P2X7 receptors (IC50 > 10 μM). Attenuates nociceptive sensitivity in animal models of pain. Orally active and brain penetrant.

Product Specifications

Molecular Weight

302.37

Formula

C16H22N4O2

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

5-[[4,5-Dimethoxy-2-(methylethyl)phenyl]methyl]-2,4-pyrimidinediamine

CAS Number

1026582-88-6

PubChem ID

11289644

InChI Key

PYNPWUIBJMVRIG-UHFFFAOYSA-N

SMILES

NC1=NC(N)=NC=C1CC2=C(C(C)C)C=C(OC)C(OC)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.24 100

Preparing Stock Solutions for RO-3

The following data is based on the product molecular weight 302.37

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.31 mL 16.54 mL 33.07 mL
5 mM 0.66 mL 3.31 mL 6.61 mL
10 mM 0.33 mL 1.65 mL 3.31 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for RO-3

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for RO-3

For research use only

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