Ro 25-6981 maleate
Tocris Bioscience, part of Bio-Techne | Catalog # 1594
GluN2B-selective NMDA antagonist
Key Product Details
Description
GluN2B-selective NMDA antagonist
Product Description
Ro 25-6981 maleate is a potent and selective activity-dependent blocker of NMDA receptors containing the GluN2B (formally NR2B) subunit. IC50 values are 0.009 and 52 μM for cloned receptor subunit combinations GluN1C/GluN2B and GluN1C/GluN2A respectively. Displays neuroprotectant effects in vivo and in vitro.Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
Product Specifications
Molecular Weight
455.55
Formula
C22H29NO2.C4H4O4
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
(αR,βS)-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol maleate
CAS Number
1312991-76-6
PubChem ID
53250677
InChI Key
FYJZEHCQSUBZDY-SEELMCCHSA-N
SMILES
OC(=O)\C=C/C(O)=O.C[C@@H](CN1CCC(CC2=CC=CC=C2)CC1)[C@@H](O)C1=CC=C(O)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 4.56 | 10 with gentle warming | |
| DMSO | 45.55 | 100 |
Preparing Stock Solutions
for Ro 25-6981 maleate
The following data is based on the product molecular weight 455.55
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.20 mL | 10.98 mL | 21.95 mL |
| 5 mM | 0.44 mL | 2.20 mL | 4.39 mL |
| 10 mM | 0.22 mL | 1.10 mL | 2.20 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kosowski and Liljequist The NR2B- selective N-MthD.-aspartate receptor antagonist Ro 25-6981 [(±)-(R*,S*)-α-(4-hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidine propanol] potentiates the effect of nicotine on locomotor activity and DA release J.Pharmacol.Exp.Ther. 2004 PMID: 15256539
- Lynch Pharmacological characterization of interactions of RO 25-6981 with the NR2B (ε2) subunit. Eur.J.Pharmacol. 2001 PMID: 11290368
- Fischer Ro 25-6981, a highly potent and selective blocker of N-MthD.-aspartate receptors containing the NR2B subunit. Characterization in vitro. J.Pharmacol.Exp.Ther. 1997 PMID: 9400004
Product Specific Notices for Ro 25-6981 maleate
For research use only
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