Key Product Details
Description: | GluN2B-selective NMDA antagonist |
Chemical Name: | (αR,βS)-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol maleate |
Purity: | ≥98% (HPLC) |
Molecular Weight: | 455.55 |
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Citations for Ro 25-6981 maleate (29)
Citations are publications that use Bio-Techne products. Selected citations for Ro 25-6981 maleate include:
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Lassus et al.
(2018)
Glutamatergic and dopaminergic modulation of cortico-striatal circuits probed by dynamic calcium imaging of networks reconstructed in microfluidic chips.
Sci Rep.
8:17461
PMID: 30498197 -
France
(2017)
Multiple roles of GluN2B-containing NMDA receptors in synaptic plasticity in juvenile hippocampus.
Neuropharmacology.
112:76
PMID: 27523302 -
Bosse et al.
(2017)
Adenylyl Cyclase 1 Is Required for Ethanol-Induced Locomotor Sensitization and Associated Increases in NMDA Receptor Phosphorylation and Function in the Dorsal Medial Striatum.
J Pharmacol Exp Ther.
363:148
PMID: 28838956 -
Volkmann et al.
(2016)
MPX-004 and MPX-007: New Pharmacological Tools to Study the Physiology of NMDA Receptors Containing the GluN2A Subunit.
PLoS One.
11:e0148129
PMID: 26829109 -
Chen et al.
(2016)
β-arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration of persistent pain.
Nature Communications.
7:12531
PMID: 27538456 -
McQuail et al.
(2016)
NR2A-Containing NMDARs in the Prefrontal Cortex Are Required for Working Memory and Associated with Age-Related Cognitive Decline.
J Neurosci.
36:12537
PMID: 27807032 -
Lauderdale et al.
(2015)
Osmotic Edema Rapidly Increases Neuronal Excitability Through Activation of NMDA Receptor-Dependent Slow Inward Currents in Juvenile and Adult Hippocampus.
ASN Neuro.
7
PMID: 26489684 -
Tindi et al.
(2015)
ANKS1B Gene Product AIDA-1 Controls Hippocampal Synaptic Transmission by Regulating GluN2B Subunit Localization.
J Neurosci.
35:8986
PMID: 26085624 -
Smith et al.
(2014)
A role for picomolar concentrations of pregnenolone sulfate in synaptic activity-dependent Ca2+ signaling and CREB activation.
Mol Pharmacol.
86:390
PMID: 25057049 -
Jiménez-Sánchez et al.
(2014)
The role of GluN2A and GluN2B subunits on the effects of NMDA receptor antagonists in modeling schizophrenia and treating refractory depression.
Neuropsychopharmacology.
39:2673
PMID: 24871546 -
Trepanier et al.
(2013)
Group II metabotropic glutamate receptors modify N-MthD.-aspartate receptors via Src kinase.
Sci Rep.
3:926
PMID: 23378895 -
Hamida et al.
(2013)
Protein tyrosine phosphatase α in the dorsomedial striatum promotes excessive ethanol-drinking behaviors.
Transl Psychiatry.
33:14369
PMID: 24005290 -
Louderback et al.
(2013)
Knockdown of BNST GluN2B-containing NMDA receptors mimics the actions of KA on novelty-induced hypophagia.
Psychoneuroendocrinology.
3:e331
PMID: 24301649 -
Urban et al.
(2013)
Treatment with a clinically-relevant dose of methylphen. alters NMDA receptor composition and synaptic plasticity in the juvenile rat prefrontal cortex.
Mol Brain.
101:65
PMID: 23333502 -
Koeglsperger et al.
(2013)
Impaired glutamate recycling and GluN2B-mediated neuronal calcium overload in mice lacking TGF-β1 in the CNS.
Glia.
61:985
PMID: 23536313 -
Liu et al.
(2013)
Long-term potentiation of synaptic transmission in the adult mouse insular cortex: multielectrode array recordings.
J Neurophysiol.
110:505
PMID: 23636718 -
Hoshiko et al.
(2012)
Deficiency of the microglial receptor CX3CR1 impairs postnatal functional development of thalamocortical synapses in the barrel cortex.
J Neurosci.
32:15106
PMID: 23100431 -
Olsen and Sheng
(2012)
NMDA receptors and BAX are essential for Aβ impairment of LTP.
Sci Rep.
2:225
PMID: 22355739 -
Bortolato et al.
(2012)
NMDARs mediate the role of monoamine oxidase A in pathological aggression.
J Neurosci.
32:8574
PMID: 22723698 -
Nebieridze et al.
(2012)
β-OE unmasks metabotropic receptor-mediated metaplasticity of NMDA receptor transmission in the female rat dentate gyrus.
PLoS One.
37:1845
PMID: 22541715 -
Ishima and Hashimoto
(2012)
Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by ifenprodil: the role of σ-1 and IP3 receptors.
Neurobiol Learn Mem.
7:e37989
PMID: 22655093 -
Noel et al.
(2011)
Tissue plasminogen activator is required for the development of fetal alcohol syndrome in mice.
Proc Natl Acad Sci U S A.
108:5069
PMID: 21383198 -
Xie et al.
(2011)
Dependence of NMDA/GSK-3β mediated metaplasticity on TRPM2 channels at hippocampal CA3-CA1 synapses.
J Neurosci.
4:44
PMID: 22188973 -
Terasaki et al.
(2010)
Activation of NR2A receptors induces ischemic tolerance through CREB signaling.
J Cereb Blood Flow Metab.
30:1441
PMID: 20145658 -
Beazely et al.
(2009)
Platelet-derived growth factor selectively inhibits NR2B-containing N-MthD.-aspartate receptors in CA1 hippocampal neurons.
J Biol Chem.
284:8054
PMID: 19106110 -
Hellier et al.
(2009)
NMDA receptor-mediated long-term alterations in epileptiform activity in experimental chronic epilepsy.
Neuropharmacology.
56:414
PMID: 18930747 -
Popp et al.
(2008)
Cerebellar granule cells cultured from adolescent rats express functional NMDA receptors: an in vitro model for studying the developing cerebellum.
J Neurochem.
106:900
PMID: 18466339 -
Niswender et al.
(2008)
Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4.
Mol Pharmacol.
74:1345
PMID: 18664603 -
Ge et al.
(2007)
A critical period for enhanced synaptic plasticity in newly generated neurons of the adult brain.
Neuron.
54:559
PMID: 17521569
There are no citations that match your criteria.
Customer Reviews for Ro 25-6981 maleate (1)
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Species: MouseAssay Type: Ex VivoCell Line/Tissue: Basolateral Amygdala SlicesWe used this drug to block NMDA receptors containing the GluN2B subunit on pyramidal neurons in the basolateral amygdala (BLA). We recorded from coronal sections of BLA and bath applied Ro 25-6981 maleate for 10 minutes.
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