Ro 08-2750
Tocris Bioscience, part of Bio-Techne | Catalog # 2272
Inhibits NGF binding to p75NTR and TrkA
Key Product Details
Description
Inhibits NGF binding to p75NTR and TrkA
Product Description
Ro 08-2750 is a non-peptide inhibitor of NGF that binds the NGF dimer (KD ~ 1 μM) possibly causing a conformational change. Selectively inhibits binding of NGF to p75NTR at submicromolar concentrations, and to both p75NTR and TrkA at concentrations > 5 μM. Prevents NGF-induced apoptosis in SK-N-MC cells. Suppresses cancer cell proliferation via regulation of Hippo signaling aand YAP phosphorylation.Product Specifications
Molecular Weight
270.24
Formula
C13H10N4O3
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
2,3,4,10-Tetrahydro-7,10-dimethyl-2,4-dioxobenzo[g]pteridine-8-carboxaldehyde
CAS Number
37854-59-4
PubChem ID
17756791
InChI Key
JDEMVNYMYPJJIM-UHFFFAOYSA-N
SMILES
CN1C2=CC(C=O)=C(C)C=C2N=C2C(=O)NC(=O)N=C12
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 2.7 | 10 with gentle warming |
Preparing Stock Solutions
for Ro 08-2750
The following data is based on the product molecular weight 270.24
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 37.00 mL | 185.02 mL | 370.04 mL |
| 0.5 mM | 7.40 mL | 37.00 mL | 74.01 mL |
| 1 mM | 3.70 mL | 18.50 mL | 37.00 mL |
| 5 mM | 0.74 mL | 3.70 mL | 7.40 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Arkin and Wells Small-molecule inhibitors of protein-protein interactions: progressing towards the dream. Nat.Rev.Drug Discov. 2004 PMID: 15060526
- Yang NTRK1 is a positive regulator of YAP oncogenic function. Oncogene 2018 PMID: 30542115
- Niederhauser NGF ligand alters NGF signaling via p75NTR and TrkA. J.Neurosci.Res. 2000 PMID: 10900073
Product Specific Notices for Ro 08-2750
For research use only
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