RN 1734
Tocris Bioscience, part of Bio-Techne | Catalog # 3746
Selective TRPV4 antagonist
Product Description
RN 1734 is a selective TRPV4 antagonist (IC50 values are 2.3, 3.2 and 5.9 μM for hTRPV4, rTRPV4 and mTRPV4 receptors respectively). Displays selectivity for TRPV4 over other TRP channels (IC50 values are 2.3, >30, >30 and >100 μM for TRPV4, TRPV3, TRPM8 and TRPV1 respectively). Blocks TRPV4-mediated arteriole vasodilation and increases myogenic tone ex vivo.Product Specifications
Molecular Weight
353.31
Formula
C14H22Cl2N2O2S
Storage
Store at +4°C
Chemical Name
2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulfonamide
CAS Number
946387-07-1
PubChem ID
3601086
InChI Key
IHYZMEAZAIFMTN-UHFFFAOYSA-N
SMILES
CC(C)NCCN(C(C)C)S(C1=C(Cl)C=C(Cl)C=C1)(=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.33 | 100 | |
| Ethanol | 17.67 | 50 |
Preparing Stock Solutions
for RN 1734
The following data is based on the product molecular weight 353.31
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.83 mL | 14.15 mL | 28.30 mL |
| 5 mM | 0.57 mL | 2.83 mL | 5.66 mL |
| 10 mM | 0.28 mL | 1.42 mL | 2.83 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.57 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Bagher Low intravascular pressure activates endothelial cell TRPV4 channels, local Ca2+ events, and IKCa channels, reducing arteriolar tone. Proc.Natl.Acad.Sci.U.S.A. 2012 PMID: 23071308
- Vincent Identification and characterization of novel TRPV4 modulators. Biochem.Biophys.Res.Comms. 2009 PMID: 19737537
Product Specific Notices for RN 1734
For research use only
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