RN 1 dihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 4977
LSD1 inhibitor
Product Description
RN 1 dihydrochloride is a potent lysine specific demethylase 1 (LSD1) inhibitor (IC50 = 70 nM). Exhibits selectivity for LSD1 over MAO-A and MAO-B (IC50 values are 0.51 and 2.79 μM for MAO-A and MAO-B, respectively). Impairs long-term, but not short-term memory in mice. Brain penetrant following systemic administration.Product Specifications
Molecular Weight
452.42
Formula
C23H29N3O2.2HCl
Storage
Store at -20°C
Purity
≥97% (HPLC)
Chemical Name
1-(4-methyl-1-piperazinyl)-2-[[(1R*,2S*)-2-[4-phenylmethoxy)phenyl]cyclopropyl]amino]ethanone dihydrochloride
CAS Number
1781835-13-9
PubChem ID
90488995
InChI Key
WMHAFZOOUBPQRX-VSIGASKDSA-N
SMILES
O=C(N4CCN(C)CC4)CN[C@@H]1C[C@H]1[C@]2=CC=C(OCC3=CC=CC=C3)C=C2.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 9.05 | 20 | |
| DMSO | 9.05 | 20 with gentle warming |
Preparing Stock Solutions
for RN 1 dihydrochloride
The following data is based on the product molecular weight 452.42
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 11.05 mL | 55.26 mL | 110.52 mL |
| 1 mM | 2.21 mL | 11.05 mL | 22.10 mL |
| 2 mM | 1.11 mL | 5.53 mL | 11.05 mL |
| 10 mM | 0.22 mL | 1.11 mL | 2.21 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Neelamegam Brain-penetrant LSD1 inhibitors can block memory consolidation. ACS Chem.Neurosci. 2012 PMID: 22754608
Product Specific Notices for RN 1 dihydrochloride
For research use only
Loading...
Loading...