Risperidone

Name: Risperidone
Brand: tocris
SKU: 2865
Rating: 4 (1 reviews)

Catalog # 2865

Citations (2)

(1)

Datasheet / COA / SDS

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Key Product Details

Description:	5-HT_2A antagonist; also D₂ antagonist; atypical antipsychotic
Alternative Names:	R 64 766
Chemical Name:	3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
Purity:	≥99% (HPLC)
Molecular Weight:	410.48

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Biological Activity

Risperidone is an atypical antipsychotic agent that displays 5-HT_2A receptor antagonism. Also displays high affinity at D₂ receptors (K_i values are 0.4 and 3.13 nM for 5-HT_2A and D₂ receptors respectively).

Technical Data

M. Wt	410.48
Formula	C₂₃H₂₇FN₄O₂
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	106266-06-2
PubChem ID	5073
InChi Key	RAPZEAPATHNIPO-UHFFFAOYSA-N
Smiles	FC1=CC2=C(C(C3CCN(CCC4=C(C)N=C(CCCC5)N5C4=O)CC3)=NO2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	4.1	10
	ethanol	4.1	10

Preparing Stock Solutions

The following data is based on the product molecular weight 410.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.36 mL	121.81 mL	243.62 mL
0.5 mM	4.87 mL	24.36 mL	48.72 mL
1 mM	2.44 mL	12.18 mL	24.36 mL
5 mM	0.49 mL	2.44 mL	4.87 mL

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References

References are publications that support the biological activity of the product.

Leysen Biochemical profile of risperidone, a new antipsychotic. J.Pharmacol.Exp.Ther. 1988 PMID: 2460616
Leysen Risperidone: a novel antipsychotic with balanced serotonin-DA antagonism, receptor occupancy profile, and pharmacologic activity. J.Clin.Psychiatry 1994 PMID: 7520908
Stathis Risperidone: a novel antipsychotic with many "atypical" properties. Psychopharmacol.
Wang Structure of the D₂ DA receptor bound to the atypical antipsychotic drug risperidone Nature 2018 PMID: 29466326

Citations (2)

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Citations are publications that use Bio-Techne products. Selected citations for Risperidone include:

Canfrán-Duque et al. (2015) Curcumin Mitigates the Intracellular Lipid Deposit Induced by Antipsychotics In Vitro. Sci Rep. 10:e0141829
PMID: 26517556
Kurita et al. (2012) HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity. Nat Neurosci. 15:1245
PMID: 22864611

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Risperidone effects in mice hyperactivity

Name: Anonymous

Species: Mouse

Assay Type: In Vivo

We found that risperidone treatment decreased hyperactivity of NF-kappa B p50 subunit KO mice, but had no effect on defective social interaction. Altogether, these data add complexity to a growing body of data, suggesting a link between dysregulation of the NF-kappa B pathway and neurodevelopmental disorders pathogenesis.

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Product Documents

COA

Certificate of Analysis

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Risperidone

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References

Citations (2)

Customer Reviews (1)

Risperidone effects in mice hyperactivity

Product Documents

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