Risperidone
Tocris Bioscience, part of Bio-Techne | Catalog # 2865
5-HT2A antagonist; also D2 antagonist; atypical antipsychotic
Key Product Details
Description
5-HT2A antagonist; also D2 antagonist; atypical antipsychotic
Alternative Names
R 64 766
Product Description
Risperidone is an atypical antipsychotic agent that displays 5-HT2A receptor antagonism. Also displays high affinity at D2 receptors (Ki values are 0.4 and 3.13 nM for 5-HT2A and D2 receptors respectively).Product Specifications
Molecular Weight
410.48
Formula
C23H27FN4O2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
CAS Number
106266-06-2
PubChem ID
5073
InChI Key
RAPZEAPATHNIPO-UHFFFAOYSA-N
SMILES
FC1=CC2=C(C(C3CCN(CCC4=C(C)N=C(CCCC5)N5C4=O)CC3)=NO2)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 4.1 | 10 | |
| Ethanol | 4.1 | 10 |
Preparing Stock Solutions
for Risperidone
The following data is based on the product molecular weight 410.48
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 24.36 mL | 121.81 mL | 243.62 mL |
| 0.5 mM | 4.87 mL | 24.36 mL | 48.72 mL |
| 1 mM | 2.44 mL | 12.18 mL | 24.36 mL |
| 5 mM | 0.49 mL | 2.44 mL | 4.87 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wang Structure of the D2 DA receptor bound to the atypical antipsychotic drug risperidone Nature 2018 PMID: 29466326
- Leysen Risperidone: a novel antipsychotic with balanced serotonin-DA antagonism, receptor occupancy profile, and pharmacologic activity. J.Clin.Psychiatry 1994 PMID: 7520908
- Stathis Risperidone: a novel antipsychotic with many "atypical" properties. Psychopharmacol.
- Leysen Biochemical profile of risperidone, a new antipsychotic. J.Pharmacol.Exp.Ther. 1988 PMID: 2460616
Product Specific Notices for Risperidone
For research use only
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