Rimcazole dihydrochloride

Name: Rimcazole dihydrochloride
Brand: Tocris Bioscience
SKU: 1497
Price: 212 USD

Tocris Bioscience a Bio-Techne Brand

Catalog # 1497

Citations (1)

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Key Product Details

Description:	σ₂ antagonist. Also DAT inhibitor
Alternative Names:	BW 234U
Chemical Name:	9-[3-(cis-3,5-Dimethyl-1-piperazinyl)propyl]-9H-carbazole dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	394.39

View Full Technical Details for Rimcazole dihydrochloride

Biological Activity for Rimcazole dihydrochloride

Rimcazole dihydrochloride is an antagonist at σ receptors (IC₅₀ values are 1480 and 386 nM at σ₁ and σ₂ receptors respectively). Also binds to the dopamine transporter (IC₅₀ = 57.6 nM) and inhibits dopamine uptake. Reduces the stimulatory effects of cocaine in vivo.

Technical Data for Rimcazole dihydrochloride

M. Wt	394.39
Formula	C₂₁H₂₇N₃.2HCl
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	75859-03-9
PubChem ID	53388
InChi Key	ZWHRZGHGYMUSRM-VWDRLOGHSA-N
Smiles	C[C@H](N[C@H](C)C4)CN4CCCN1C3=C(C=CC=C3)C2=C1C=CC=C2.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Rimcazole dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	3.94	10

Preparing Stock Solutions for Rimcazole dihydrochloride

The following data is based on the product molecular weight 394.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.36 mL	126.78 mL	253.56 mL
0.5 mM	5.07 mL	25.36 mL	50.71 mL
1 mM	2.54 mL	12.68 mL	25.36 mL
5 mM	0.51 mL	2.54 mL	5.07 mL

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References for Rimcazole dihydrochloride

References are publications that support the biological activity of the product.

Matsumoto Rimcazole analogs attenuate the convulsive effects of cocaine: correlation with binding to sigma receptors rather than DA transporters. Neuropharmacology 2001 PMID: 11684152
Husbands Isothiocyanate derivatives of 9-[3-(cis-3,5-dimethyl-1-piperazinyl)propyl]-carbazole (Rimcazole): irreversible ligands for the DA transporter. J.Med.Chem. 1997 PMID: 9435903
Ferris Evidence that the potential antipsychotic agent rimcazole (BW 234U) is a specific, competitive antagonist of sigma sites in brain. Life Sci. 1986 PMID: 2873494

Citations for Rimcazole dihydrochloride (1)

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Citations are publications that use Bio-Techne products. Selected citations for Rimcazole dihydrochloride include:

Rennekamp et al. (2016) σ1 receptor ligands control a switch between passive and active threat responses. Nat Chem Biol. 12:552
PMID: 27239788

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