Riluzole hydrochloride

Name: Riluzole hydrochloride
Brand: Tocris Bioscience
SKU: 0768

Tocris Bioscience, part of Bio-Techne | Catalog # 0768

Citations (26)

COA / SDS

GABA uptake inhibitor; also inhibits glutamate release and blocks NaV channels

Key Product Details

Description:	GABA uptake inhibitor; also inhibits glutamate release and blocks Na_V channels
Chemical Name:	2-Amino-6-trifluoromethoxybenzothiazole hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	270.66

View Full Technical Details for Riluzole hydrochloride

Technical Data
Citations

Biological Activity for Riluzole hydrochloride

Inhibits glutamate release from presynaptic terminals and increases Na⁺-dependent glutamate uptake in rat cortical synaptosomes. Blocks voltage-dependent Na⁺ channels and inhibits GABA uptake by striatal synaptosomes. Also activates TRPC5 channels. Psychotropic agent with anticonvulsant, hypnotic, anxiolytic, anti-ischemic, anesthetic and neuroprotective properties.

Technical Data for Riluzole hydrochloride

M. Wt	270.66
Formula	C₈H₅F₃N₂OS.HCl
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	850608-87-6
PubChem ID	6419992
InChi Key	QEAOELIJQRYJJS-UHFFFAOYSA-N
Smiles	Cl.NC1=NC2=CC=C(OC(F)(F)F)C=C2S1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Riluzole hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	27.07	100
	water	2.71	10 with gentle warming

Preparing Stock Solutions for Riluzole hydrochloride

The following data is based on the product molecular weight 270.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.69 mL	18.47 mL	36.95 mL
5 mM	0.74 mL	3.69 mL	7.39 mL
10 mM	0.37 mL	1.85 mL	3.69 mL
50 mM	0.07 mL	0.37 mL	0.74 mL

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References for Riluzole hydrochloride

References are publications that support the biological activity of the product.

Richter Riluzole activates TRPC5 channels independently of PLC activity. Br.J.Pharmacol. 2014 PMID: 24117252
Umeniya and Berger Inhibition by Riluzole of glycinergic postsynaptic currents in rat hypoglossal motoneurones. Br.J.Pharmacol. 1995 PMID: 8719800
Song Differential action of Riluzole on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels. J.Pharmacol.Exp.Ther. 1997 PMID: 9262334
Taylor and Meldrum Na⁺ channels as targets for neuroprotective drugs. TiPS 1995 PMID: 7482996
Fumagalli Riluzole enhances the activity of glutamate transporters GLAST, GLT1 and EAAC1. Eur.J.Pharmacol. 2008 PMID: 18036519