Riluzole hydrochloride

Name: Riluzole hydrochloride
Brand: Tocris Bioscience
SKU: 0768
Price: 124 USD

Tocris Bioscience a Bio-Techne Brand

Catalog # 0768

Citations (15)

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Key Product Details

Description:	GABA uptake inhibitor; also inhibits glutamate release and blocks Na_V channels
Chemical Name:	2-Amino-6-trifluoromethoxybenzothiazole hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	270.66

View Full Technical Details for Riluzole hydrochloride

Biological Activity for Riluzole hydrochloride

Inhibits glutamate release from presynaptic terminals and increases Na⁺-dependent glutamate uptake in rat cortical synaptosomes. Blocks voltage-dependent Na⁺ channels and inhibits GABA uptake by striatal synaptosomes. Also activates TRPC5 channels. Psychotropic agent with anticonvulsant, hypnotic, anxiolytic, anti-ischemic, anesthetic and neuroprotective properties.

Technical Data for Riluzole hydrochloride

M. Wt	270.66
Formula	C₈H₅F₃N₂OS.HCl
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	850608-87-6
PubChem ID	6419992
InChi Key	QEAOELIJQRYJJS-UHFFFAOYSA-N
Smiles	Cl.NC1=NC2=CC=C(OC(F)(F)F)C=C2S1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Riluzole hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	27.07	100
	water	2.71	10 with gentle warming

Preparing Stock Solutions for Riluzole hydrochloride

The following data is based on the product molecular weight 270.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.69 mL	18.47 mL	36.95 mL
5 mM	0.74 mL	3.69 mL	7.39 mL
10 mM	0.37 mL	1.85 mL	3.69 mL
50 mM	0.07 mL	0.37 mL	0.74 mL

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References for Riluzole hydrochloride

References are publications that support the biological activity of the product.

Richter Riluzole activates TRPC5 channels independently of PLC activity. Br.J.Pharmacol. 2014 PMID: 24117252
Fumagalli Riluzole enhances the activity of glutamate transporters GLAST, GLT1 and EAAC1. Eur.J.Pharmacol. 2008 PMID: 18036519
Song Differential action of Riluzole on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels. J.Pharmacol.Exp.Ther. 1997 PMID: 9262334
Taylor and Meldrum Na⁺ channels as targets for neuroprotective drugs. TiPS 1995 PMID: 7482996
Umeniya and Berger Inhibition by Riluzole of glycinergic postsynaptic currents in rat hypoglossal motoneurones. Br.J.Pharmacol. 1995 PMID: 8719800

Citations for Riluzole hydrochloride (15)

Showing 1 - 10 of 15 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Riluzole hydrochloride include:

Zhang et al. (2018) Pauses in Cholinergic Interneuron Activity Are Driven by Excitatory Input and Delayed Rectification, with DA Modulation. Neuron. 98:918
PMID: 29754751
Shin et al. (2018) Participation of xCT in melanoma cell proliferation in vitro and tumorigenesis in vivo. Oncogenesis. 7:86
PMID: 30425240
Sexton et al. (2018) Metabotropic glutamate receptor-1 regulates inflammation in triple negative breast cancer. Sci Rep. 8:16008
PMID: 30375476
Dolfi et al. (2017) R.zole exerts distinct antitumor effects from a metabotropic glutamate receptor 1-specific inhibitor on breast cancer cells. Oncotarget. 8:44639
PMID: 28591718
Sperling et al. (2017) Riluzole: a potential therapeutic intervention in human brain tumor stem-like cells. Oncotarget. 8:96697
PMID: 29228563
Du et al. (2015) Generation and expansion of highly pure motor neuron progenitors from human pluripotent stem cells. Nat Commun. 6:6626
PMID: 25806427
Rosenberg et al. (2015) Targeting Glutamatergic Signaling and the PI3 Kinase Pathway to Halt Melanoma Progression. Front Neural Circuits. 8:42614
PMID: 25749171
Du et al. (2015) Generation and expansion of highly pure motor neuron progenitors from human pluripotent stem cells. Nat.Commun.. 6:6626
PMID: 25806427
Veettil et al. (2014) Glutamate secretion and metabotropic glutamate receptor 1 expression during Kaposi's sarcoma-associated herpesvirus infection promotes cell proliferation. PLoS Pathog. 10:e1004389
PMID: 25299066
Viemari et al. (2013) β-Noradrenergic receptor activation specifically modulates the generation of sighs in vivo and in vitro. Neurochem Int. 7:179
PMID: 24273495
Park et al. (2013) Slowly inactivating component of Na+ current in peri-somatic region of hippocampal CA1 pyramidal neurons. J Neurophysiol. 109:1378
PMID: 23236005
Carbone et al. (2012) R.zole elevates GLT-1 activity and levels in striatal astrocytes. BMC Neurosci. 60:42613
PMID: 22080156
Carbone et al. (2012) R.zole neuroprotection in a Parkinson's disease model involves suppression of reactive astrocytosis but not GLT-1 regulation. Cells. 13:38
PMID: 22480308
Le et al. (2010) The glutamate release inhibitor R.zole decreases migration, invasion, and proliferation of melanoma cells. J Invest Dermatol. 130:2240
PMID: 20505744
Morgado-Valle et al. (2010) Glycinergic pacemaker neurons in preBötzinger complex of neonatal mouse. J Neurosci. 30:3634
PMID: 20219997

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