Rilpivirine

Name: Rilpivirine
Brand: Tocris Bioscience
SKU: 7684

Tocris Bioscience, part of Bio-Techne | Catalog # 7684

COA / SDS

Non-nucleoside reverse transcriptase inhibitor

Key Product Details

Description:	Non-nucleoside reverse transcriptase inhibitor
Chemical Name:	4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
Purity:	≥98% (HPLC)
Molecular Weight:	366.42

View Full Technical Details for Rilpivirine

Technical Data
Citations

Biological Activity for Rilpivirine

Rilpivirine is a potent diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). It has high antiviral activity against wild-type HIV-1 and mutant viruses (EC₅₀ values are 0.4 and 0.1-2.0 nM, respectively in a cell-based assay). This compound is orally bioavailable.

Technical Data for Rilpivirine

M. Wt	366.42
Formula	C₂₂H₁₈N₆
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	500287-72-9
PubChem ID	6451164
InChi Key	YIBOMRUWOWDFLG-ONEGZZNKSA-N
Smiles	N(C1=C(C)C=C(/C=C/C#N)C=C1C)C2=NC(NC3=CC=C(C#N)C=C3)=NC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Rilpivirine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	18.32	50

Preparing Stock Solutions for Rilpivirine

The following data is based on the product molecular weight 366.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.46 mL	27.29 mL	54.58 mL
2.5 mM	1.09 mL	5.46 mL	10.92 mL
5 mM	0.55 mL	2.73 mL	5.46 mL
25 mM	0.11 mL	0.55 mL	1.09 mL

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Reconstitution Calculator

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References for Rilpivirine

References are publications that support the biological activity of the product.

Baert Development of a long-acting injectable formulation with nanoparticles of rilpivirine (TMC278) for HIV treatment. Eur.J.Pharm.Biopharm. 2009 PMID: 19328850
Janssen In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile (R278474, rilpivirine) J.Med.Chem. 2005 PMID: 15771434